ArticleNature2017
Global translational reprogramming is a fundamental layer of immune regulation in plants.
Article in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers.
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Who cites it
130 citing papers in PubMed, 247 citations in OpenAlex.
- Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026Review
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- Integrating single-cell omic techniques to resolve the spatio-temporal complexity of arbuscular mycorrhizal symbiosis.Journal of experimental botany · 2026Review
- Epigenetic regulation of TaFIP phytocytokine clusters confers basal resistance via receptor kinase TaFIPR in wheat.Nature plants · 2026Article
- Subfamily-level comparative transcriptomics of key immune regulators in plants and suspension cells reveals novel rice blast resistance genes.Plant & cell physiology · 2026Article
- Paradoxical Immune Phenotypes and Dual-State Immune Regulators in Plants: The GSL5 Case Study.International journal of molecular sciences · 2026Review
- Plant Peptides on the Rise: From Historical Insight to Future Applications.Plant biotechnology journal · 2026Review
- Multi-Omics Analysis Identifies SlLhcb13 as a Key Regulator of Tomato Resistance toPlants (Basel, Switzerland) · 2026Article
- Exploiting plant immune "switches" for resistance engineering.Stress biology · 2026Review
- Bacteria use P-body condensates to attenuate host translation during infection.Science advances · 2026Article
- Field Root-Associated Microbiome Characteristics ofJournal of fungi (Basel, Switzerland) · 2026Article
- The birth, death, and evolutionary compensation of uORFs in Drosophila.Nucleic acids research · 2026Article
- Welcome Pathogens: Transient Heat Dampens Immune Responses to Acibenzolar-S-Methyl in Apple Plants.Plant, cell & environment · 2026Article
- Leaf it to science: Uncovering plant immune systems through technological advances.Plant physiology · 2026Review
- Global atlas of enhancer-promoter interactome in cotton genome revealed by profiling RNA-RNA spatial interactions.Genome biology · 2026Article
- Translational control in plants: from basic mechanisms to environmental and developmental responses.The Plant journal : for cell and molecular biology · 2026Review
- Seamless, modular binary vectors for plant cell and molecular biology.Plant biotechnology journal · 2026Article
- Integrated multi-omics analysis reveals hormonal and nutrient networks regulating sugarcane tillering.Frontiers in plant science · 2026Article
- Article
70 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
In the absence of specialized immune cells, the need for plants to reprogram transcription to transition from growth-related activities to defence is well understood. However, little is known about translational changes that occur during immune induction. Using ribosome footprinting, here we perform global translatome profiling on Arabidopsis exposed to the microbe-associated molecular pattern elf18. We find that during this pattern-triggered immunity, translation is tightly regulated and poorly correlated with transcription. Identification of genes with altered translational efficiency leads to the discovery of novel regulators of this immune response. Further investigation of these genes shows that messenger RNA sequence features are major determinants of the observed translational efficiency changes. In the 5' leader sequences of transcripts with increased translational efficiency, we find a highly enriched messenger RNA consensus sequence, R-motif, consisting of mostly purines. We show that R-motif regulates translation in response to pattern-triggered immunity induction through interaction with poly(A)-binding proteins. Therefore, this study provides not only strong evidence, but also a molecular mechanism, for global translational reprogramming during pattern-triggered immunity in plants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.