Evidence map›Paper›PMID 28514281›Full record

ArticleAIDS (London, England)2017

Acute hyperinsulinemia effects on systemic markers of immune activation in HIV.

Timothy K O'Malley, Tricia H Burdo, Jake A Robinson, Kathleen V Fitch, Steven K Grinspoon, Suman Srinivasa

Abstract read
In one paragraph

Article in AIDS (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Timothy K O'MalleyaProgram in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts bDepartment of Neuroscience, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.
Tricia H Burdo
Jake A Robinson
Kathleen V Fitch
Steven K Grinspoon
Suman Srinivasa
Massachusetts General Hospital · USTemple University · USHarvard University · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Alessio Fasano · 1994 to 2026
$31.6M
Harvard Clinical and Translational Science Center (UL1)UL1TR000170 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2012 to 2013
$31.4M
TESTOSTERONE AND GROWTH HORMONE EFFECTS IN AIDS WASTINGR01DK049302 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI ADLER, GAIL KURR, GRINSPOON, STEVEN K. · 1995 to 2020
$12.2M
Aldosterone and Diabetic Cardiovascular Disease: Research and Mentoring ProgamK24HL103845 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ADLER, GAIL KURR · 2011 to 2021
$1.6M
Physiologic Investigation of the Renin-Angiotensin-Aldosterone System to Understand Arterial Inflammation in HIVK23HL136262 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SRINIVASA, SUMAN · 2017 to 2021
$960k
NCATS NIH HHS UL1 TR000170NCATS NIH HHS UL1 TR001102NCRR NIH HHS UL1 RR025758NHLBI NIH HHS K23 HL136262NHLBI NIH HHS K24 HL103845NIDDK NIH HHS P30 DK040561NIDDK NIH HHS R01 DK049302
6 · The paper itself

Abstract

: The well treated HIV population remains at risk for insulin resistance and chronic immune activation. We tested the effects of acute hyperinsulinemia on inflammation in HIV. Twenty HIV-infected and 10 non-HIV-infected individuals well matched for BMI underwent oral glucose tolerance testing to stimulate insulin secretion and assess for changes in circulating soluble CD163, soluble CD14, and monocyte chemoattract protein 1. Soluble CD14 decreased significantly after stimulation of hyperinsulinemia and no significant changes in soluble CD163 or monocyte chemoattract protein 1 were demonstrated in HIV-infected and non-HIV-infected groups.

Indexed as

AdolescentAdultAgedAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenChemokine CCL2FemaleGlucose Tolerance TestHIV InfectionsHumansHyperinsulinismInflammationLipopolysaccharide ReceptorsMaleMiddle AgedAntigens, CDAntigens, Differentiation, MyelomonocyticCCL2 protein, humanCD163 AntigenChemokine CCL2Lipopolysaccharide ReceptorsReceptors, Cell Surface

Identifiers

PMID28514281
PMCPMC5524206
OpenAlexW2614835228

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.