ArticleJournal of medicinal food2017
Piceatannol Reduces Fat Accumulation in Caenorhabditis elegans.
Article in Journal of medicinal food, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- UtilizingPreventive nutrition and food science · 2026Review
- Development of New Red-Fleshed Seedless Table Grapes: In Vitro Insights on Glucose Absorption and Insulin Resistance Biomarkers.Foods (Basel, Switzerland) · 2025Article
- Flowers ofAntioxidants (Basel, Switzerland) · 2023Article
- Piceatannol antagonizes lipolysis by promoting autophagy-lysosome-dependent degradation of lipolytic protein clusters in adipocytes.The Journal of nutritional biochemistry · 2022Article
- Article
- Saponins from bitter melon reduce lipid accumulation via induction of autophagy inCurrent research in food science · 2022Article
- Litchi flower essential oil balanced lipid metabolism through the regulation of DAF-2/IIS, MDT-15/SBP-1, and MDT-15/NHR-49 pathway.Frontiers in nutrition · 2022Article
- Article
- Curcumin reduced fat accumulation inCurrent research in food science · 2021Article
- Azelaic Acid Promotes Caenorhabditis elegans Longevity at Low Temperature Via an Increase in Fatty Acid Desaturation.Pharmaceutical research · 2021Article
- Perfluorooctanesulfonic acid (PFOS) and perfluorobutanesulfonic acid (PFBS) impaired reproduction and altered offspring physiological functions in Caenorhabditis elegans.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020Article
- Piceatannol attenuates fat accumulation and oxidative stress in steatosis-induced HepG2 cells.Current research in food science · 2020Article
- Fat-lowering effects of isorhamnetin are via NHR-49-dependent pathway inCurrent research in food science · 2020Article
- Epigallocatechin-3-Gallate Reduces Fat Accumulation inPreventive nutrition and food science · 2018Article
- The Dietary Antioxidant Piceatannol Inhibits Adipogenesis of Human Adipose Mesenchymal Stem Cells and Limits Glucose Transport and Lipogenic Activities in Adipocytes.International journal of molecular sciences · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excess fat accumulation and abnormal metabolism are involved in numerous diseases and thus the research on identification of compounds that can regulate energy homeostasis could significantly facilitate the current effort to prevent and/or treat metabolic disorders. Piceatannol, one of the natural stilbenes, was previously found to decrease lipid accumulation of 3T3-L1 adipocytes. However, its role in fat metabolism in vivo is not known. Thus, Caenorhabditis elegans as an animal model was used in the current study to determine the effect of piceatannol on fat accumulation and its underlying mechanisms. The results showed that 50 and 100 μM piceatannol significantly reduced fat accumulation of wild-type worms grown in normal and high-glucose conditions without altering the growth rate, worm length, pumping rate, or moving speed. The current study further indicated that piceatannol decreased the expression of sbp-1 (encodes an ortholog of mammalian sterol regulatory element-binding protein) and its target gene fasn-1 (encodes an ortholog of fatty acid synthase) as well as increased the expression of hosl-1 (encodes an ortholog of hormone-sensitive lipase) in glucose-treated worms. These data suggested that piceatannol reduced fat accumulation in C. elegans by suppression of genes involved in lipid synthesis and possibly through stimulation of lipolysis. Given that piceatannol exerts similar effects in both C. elegans and 3T3-L1 cells, our finding could provide a mechanistic insight into the role of piceatannol in lipid metabolism in mammals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.