ArticleSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)2017
Repeatability of vessel density measurement in human skin by OCT-based microangiography.
Article in Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Quantification of Skin Adaptation to Lower-Limb Prosthesis Use Through Optical Coherence Tomography Angiography and Thermal Imaging: A Review.Bioengineering (Basel, Switzerland) · 2026Review
- Design and implementation of an integrated scanning protocol for multimodal functional OCT.Biomedical optics express · 2025Article
- Quantitative assessment of the oral microvasculature using optical coherence tomography angiography.Frontiers in bioengineering and biotechnology · 2024Article
- Pilot study of optical coherence tomography angiography-derived microvascular metrics in hands and feet of healthy and diabetic people.Scientific reports · 2023Article
- Development of a Vascularized Human Skin Equivalent with Hypodermis for Photoaging Studies.Biomolecules · 2022Article
- High resolution imaging and quantification of the nailfold microvasculature using optical coherence tomography angiography (OCTA) and capillaroscopy: a preliminary study in healthy subjects.Quantitative imaging in medicine and surgery · 2022Article
- Automatic 3D adaptive vessel segmentation based on linear relationship between intensity and complex-decorrelation in optical coherence tomography angiography.Quantitative imaging in medicine and surgery · 2021Article
- OCTAVA: An open-source toolbox for quantitative analysis of optical coherence tomography angiography images.PloS one · 2021Article
- Imaging Motion: A Comprehensive Review of Optical Coherence Tomography Angiography.Advances in experimental medicine and biology · 2021Review
- Polarization sensitive optical coherence tomography for imaging microvascular information within living tissue without polarization-induced artifacts.Biomedical optics express · 2020Article
- Automatic skin lesion area determination of basal cell carcinoma using optical coherence tomography angiography and a skeletonization approach: Preliminary results.Journal of biophotonics · 2019Article
- Optical coherence tomography angiography monitors human cutaneous wound healing over time.Quantitative imaging in medicine and surgery · 2018Article
- Article
- Automatic motion correction for in vivo human skin optical coherence tomography angiography through combined rigid and nonrigid registration.Journal of biomedical optics · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo investigate the repeatability of vessel density measurement at human arm skin in healthy subjects with OCT-based microangiography (OMAG).
methodsFour locations including volar wrist, volar forearm, shoulder, and volar upper arm were scanned using an optimized swept source OCT system, working at center wavelength of 1300 nm and A-line rate of 100 kHz. Three scans were acquired at each location at the same visit. Vascular images of papillary dermis, reticular dermis, and the whole dermis layer were generated with OMAG processing and automatic segmentation algorithms. The vessel density (VD) of each layer was calculated based on vascular images, and the repeatability of the VD at the same physiological location was thereafter assessed.
resultsFifteen healthy volunteers were included. High repeatability of VD was found for wrist, forearm, shoulder, and upper arm (coefficient of variation (CV)=2.4, 2.7, 2.7, 2.0, and intraclass correlation coefficient (ICC)=0.906, 0.854, 0.943, 0.916 respectively). The VD measurements showed no significant difference between the four locations in any of the three layers, ie papillary layer (P=.1063), reticular layer (P=.3371), and whole dermis layer (P=.3233).
conclusionQuantification of VD by using OCT/OMAG is repeatable when imaging skin tissue beds in healthy individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.