Evidence map›Paper›PMID 28513837›Full record

Observational studyInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2017

Maternal near miss in low-resource areas.

Robert L Goldenberg, Sarah Saleem, Sumera Ali, Janet L Moore, Adrien Lokangako, Antoinette Tshefu, Musaku Mwenechanya, Elwyn Chomba, Ana Garces, Lester Figueroa and 20 more

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03871491 (Prevention of Maternal and Neonatal Death/Infections With a Single Oral Dose of Azithromycin in Women in Labor), which is not on this map. Cited by 28 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03871491 phase3completednot on this mapstarted 2020, after this paper: background citation

Prevention of Maternal and Neonatal Death/Infections With a Single Oral Dose of Azithromycin in Women in Labor (in Low- and Middle-income Countries): a Randomized Controlled Trial

TypeinterventionalSponsorNICHD Global Network for Women's and Children's HealthRan2020 to 2022Enrolled58,747ConditionsMaternal Death, Maternal Infections Affecting Fetus or Newborn, Neonatal SEPSIS, Maternal Sepsis During LaborArmsAzithromycin, Placebo
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Pooled it
  6. Trial
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  13. Examining maternal morbidity across a spectrum of delivery locations: An analysis of the Global Network's Maternal and Neonatal Health Registry.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2023
    Article
  14. Indicators for maternal near miss: an observational study, India.Bulletin of the World Health Organization · 2022
    Observational
  15. Article
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  19. Obstetric anaesthesia as a career.Indian journal of anaesthesia · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Robert L GoldenbergDepartment of Obstetrics and Gynecology, Columbia University School of Medicine, New York, NY, USA.
Sarah SaleemDepartment of Community Health Sciences, Aga Khan University, Karachi, Pakistan.
Sumera AliDepartment of Community Health Sciences, Aga Khan University, Karachi, Pakistan.
Janet L MooreSocial, Statistical and Environmental Health Sciences, RTI International, Durham, NC, USA.
Adrien LokangakoSchool of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Antoinette TshefuSchool of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Musaku MwenechanyaDepartment of Pediatrics, University of Zambia, Lusaka, Zambia.
Elwyn ChombaDepartment of Pediatrics, University of Zambia, Lusaka, Zambia.
Ana GarcesMaternal and Child Health, INCAP, Guatemala City, Guatemala.
Lester FigueroaMaternal and Child Health, INCAP, Guatemala City, Guatemala.
Shivaprasad GoudarJawaharlal Nehru Medical Center, KLE University, Belagavi, India.
Bhalachandra KodkanyJawaharlal Nehru Medical Center, KLE University, Belagavi, India.
Archana PatelLata Medical Research Foundation, Nagpur, India.
Fabian EsamaiSchool of Medicine, Moi University, Eldoret, Kenya.
Paul NsyongeSchool of Medicine, Moi University, Eldoret, Kenya.
Margo S HarrisonDepartment of Obstetrics and Gynecology, Columbia University School of Medicine, New York, NY, USA.
Melissa BausermanDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Carl L BoseDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nancy F KrebsDepartment of Pediatrics, University of Colorado, Denver, CO, USA.
K Michael HambidgeDepartment of Pediatrics, University of Colorado, Denver, CO, USA.
Richard J DermanSchool of Global Public Health, Thomas Jefferson University, Philadelphia, PA, USA.
Patricia L HibberdSchool of Global Health, Boston University, Boston, MA, USA.
Edward A LiechtyDepartment of Pediatrics, Indiana University, Indianapolis, IN, USA.
Dennis D WallaceSocial, Statistical and Environmental Health Sciences, RTI International, Durham, NC, USA.
Jose M BelizanIECS University of Buenos Aires, Buenos Aires, Argentina.
Menachem MiodovnikPerinatology and Pregnancy Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD, USA.
Marion Koso-ThomasPerinatology and Pregnancy Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD, USA.
Waldemar A CarloDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Alan H JobeDepartment of Pediatrics, Cincinnati Hospital for Children, Cincinnati, OH, USA.
Elizabeth M McClureSocial, Statistical and Environmental Health Sciences, RTI International, Durham, NC, USA.

Funding

Zika in Pregnancy Supplemental Funding requestU01HD040636 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI MCCLURE, ELIZABETH M · 2001 to 2017
$37.5M
UAB/AKU Global Network Research UnitU01HD040607 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GOLDENBERG, ROBERT L · 2001 to 2012
$8.5M
Complementary feeding: a Global Network cluster randomized controlled trialU01HD040657 · NICHD · UNIVERSITY OF COLORADO DENVER · PI HAMBIDGE, K MICHAEL · 2001 to 2012
$8.1M
UMKC-JNMC Global Network for Women's and Children's Health Research UnitU01HD042372 · NICHD · UNIVERSITY OF MISSOURI KANSAS CITY · PI DERMAN, RICHARD J · 2001 to 2012
$6.9M
Neonatal Resuscitation in Developing CountriesU01HD043464 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CARLO FONT, WALDEMAR A. · 2003 to 2012
$6.6M
Evidence-Based Global Health Interventions for Mothers and Children, ArgentinaU01HD040477 · NICHD · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI BUEKENS, PIERRE · 2001 to 2013
$5.6M
Boston University/Lata Medical Research Foundation Global Network for Women's Children's Health Research UnitUG1HD078439 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Patricia L Hibberd · 2018 to 2026
$5.5M
TJU-JNMC Global Network for Women's & Children's Health Research UnitUG1HD076457 · NICHD · THOMAS JEFFERSON UNIVERSITY · PI RICHARD J DERMAN · 2018 to 2026
$5.5M
Nutrition-specific interventions to improve long-term maternal-child health outcomesUG1HD076474 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Edwin Jose Asturias, NANCY F KREBS · 2018 to 2026
$5.4M
The Global Network and Preconception Maternal NutritionU10HD076474 · NICHD · UNIVERSITY OF COLORADO DENVER · PI KREBS, NANCY F · 2013 to 2017
$5.1M
Improving Quality of Care for the Treatment of Childhood PneumoniaU01HD058322 · NICHD · TUFTS UNIVERSITY BOSTON · PI HIBBERD, PATRICIA L · 2008 to 2012
$4.0M
CCHS-JNMC Global Network for Women's & Children's Health Research UnitU10HD076457 · NICHD · THOMAS JEFFERSON UNIVERSITY · PI DERMAN, RICHARD J · 2013 to 2017
$3.7M
NICHD NIH HHS U01 HD040477NICHD NIH HHS U01 HD040607NICHD NIH HHS U01 HD040636NICHD NIH HHS U01 HD040657NICHD NIH HHS U01 HD042372NICHD NIH HHS U01 HD043464NICHD NIH HHS U01 HD058322NICHD NIH HHS U01 HD058326NICHD NIH HHS U10 HD076457NICHD NIH HHS U10 HD076465NICHD NIH HHS U10 HD076474NICHD NIH HHS U10 HD078438NICHD NIH HHS U10 HD078439NICHD NIH HHS UG1 HD076457NICHD NIH HHS UG1 HD076474NICHD NIH HHS UG1 HD078439
6 · The paper itself

Abstract

objectiveTo describe the Global Network Near-Miss Maternal Mortality System and its application in seven sites.

methodsIn a population-based study, pregnant women eligible for enrollment in the Maternal and Newborn Health Registry at seven sites (Democratic Republic of the Congo; Guatemala; Belagavi and Nagpur, India; Kenya; Pakistan; and Zambia) between January 2014 and April 2016 were screened to identify those likely to have a near-miss event. The WHO maternal near-miss criteria were modified for low-resource settings. The ratio of near-miss events to maternal deaths was calculated.

resultsAmong 122 707 women screened, 18 307 (15.0%) had a potential near-miss event, of whom 4866 (26.6%; 4.0% of all women) had a near-miss maternal event. The overall maternal mortality ratio was 155 per 100 000 live births. The ratio of near-miss events to maternal deaths was 26 to 1. The most common factors involved in near-miss cases were the hematologic/coagulation system, infection, and cardiovascular system.

conclusionBy using the Global Network Near-Miss Maternal Mortality System, large numbers of women were screened for near-miss events, including those delivering at home or a low-level maternity clinic. The 4.0% incidence of near-miss maternal mortality is similar to previously reported data. The ratio of 26 near-miss cases to 1 maternal death suggests that near miss might evaluate the impact of interventions more efficiently than maternal mortality.

Indexed as

Maternal MortalityMedically Underserved AreaDeveloping CountriesFemaleHospitals, MaternityHumansMaternal Health ServicesObstetric Labor ComplicationsPregnancyPregnancy ComplicationsProspective StudiesRegistriesLow- and middle-income countriesMaternal mortalityMaternal near miss

Identifiers

PMID28513837
PMCPMC5603206

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.