Evidence map›Paper›PMID 28513319›Full record

ArticleNanotoxicology2017

Effect of surface functionalizations of multi-walled carbon nanotubes on neoplastic transformation potential in primary human lung epithelial cells.

Todd A Stueckle, Donna C Davidson, Ray Derk, Peng Wang, Sherri Friend, Diane Schwegler-Berry, Peng Zheng, Nianqiang Wu, Vince Castranova, Yon Rojanasakul and 1 more

Open access · greenAbstract read
In one paragraph

Article in Nanotoxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Todd A Stuecklea Health Effects Laboratory Division , National Institute for Occupational Safety and Health , Morgantown , WV , USA.
Donna C Davidsona Health Effects Laboratory Division , National Institute for Occupational Safety and Health , Morgantown , WV , USA.
Ray Derka Health Effects Laboratory Division , National Institute for Occupational Safety and Health , Morgantown , WV , USA.
Peng Wangb Department of Pharmaceutical Sciences, School of Pharmacy , West Virginia University , Morgantown , WV , USA.
Sherri Frienda Health Effects Laboratory Division , National Institute for Occupational Safety and Health , Morgantown , WV , USA.
Diane Schwegler-Berrya Health Effects Laboratory Division , National Institute for Occupational Safety and Health , Morgantown , WV , USA.
Peng Zhengc Department of Mechanical and Aerospace Engineering , West Virginia University , Morgantown , WV , USA.
Nianqiang Wuc Department of Mechanical and Aerospace Engineering , West Virginia University , Morgantown , WV , USA.
Vince Castranovab Department of Pharmaceutical Sciences, School of Pharmacy , West Virginia University , Morgantown , WV , USA.
Yon Rojanasakulb Department of Pharmaceutical Sciences, School of Pharmacy , West Virginia University , Morgantown , WV , USA.
Liying Wanga Health Effects Laboratory Division , National Institute for Occupational Safety and Health , Morgantown , WV , USA.
National Institute for Occupational Safety and Health · USWest Virginia University · US

Funding

Induction of Neoplastic Transformation and Cancer Stem Cells by Carbon NanotubesR01ES022968 · NIEHS · WEST VIRGINIA UNIVERSITY · PI ROJANASAKUL, YON · 2014 to 2019
$1.7M
Nanoparticle Fibrogenicity and Fibroblast Stem-Like CellsR01EB018857 · NIBIB · WEST VIRGINIA UNIVERSITY · PI ROJANASAKUL, YON · 2016 to 2019
$1.3M
NIBIB NIH HHS R01 EB018857NIEHS NIH HHS R01 ES022968
6 · The paper itself

Abstract

Functionalized multi-walled carbon nanotube (fMWCNT) development has been intensified to improve their surface activity for numerous applications, and potentially reduce toxic effects. Although MWCNT exposures are associated with lung tumorigenesis in vivo, adverse responses associated with exposure to different fMWCNTs in human lung epithelium are presently unknown. This study hypothesized that different plasma-coating functional groups determine MWCNT neoplastic transformation potential. Using our established model, human primary small airway epithelial cells (pSAECs) were continuously exposed for 8 and 12 weeks at 0.06 μg/cm

Indexed as

Epithelial CellsCells, CulturedCell Transformation, NeoplasticHumansLungNanotubes, CarbonSurface PropertiesNanotubes, Carbonaging effectscell transformationfunctionalizationmulti-walled carbon nanotubesSurface properties

Identifiers

PMID28513319
PMCPMC5774008
OpenAlexW2614792156

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.