ArticleAnalytical chemistry2017
Sensitive Analysis of Protein Adsorption to Colloidal Gold by Differential Centrifugal Sedimentation.
Article in Analytical chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 68 citations in OpenAlex.
- Rapid Determination of SiOThe journal of physical chemistry. C, Nanomaterials and interfaces · 2026Article
- Controlling Macrophage Uptake of Gold Nanoparticles through the Design of an Effective Heterogeneous Coating.ACS applied materials & interfaces · 2026Article
- Bio Meets Nano: Protein Exchange in Saline Biocoronae on Magnetic Nanoparticles.International journal of molecular sciences · 2025Article
- Surface Functionalization of Nanoparticles for Enhanced Electrostatic Adsorption of Biomolecules.Molecules (Basel, Switzerland) · 2025Review
- Design Principles for Engineering Ionic Liquid-Gold Nanoparticles for Therapeutic Delivery to the Brain.ACS nano · 2025Article
- Biotransformation and biological fate of magnetic iron oxide nanoparticles for biomedical research and clinical applications.Nanoscale advances · 2025Review
- Probing Solid-Binding Peptide Self-Assembly Kinetics Using a Frequency Response Cooperativity Model.Biomimetics (Basel, Switzerland) · 2025Article
- Protein Corona of Nanoparticles: Isolation and Analysis.Chem & bio engineering · 2024Review
- Label free tracking to quantify nanoparticle diffusion through biological media.Scientific reports · 2024Article
- A comprehensive investigation of the interactions of human serum albumin with polymeric and hybrid nanoparticles.Drug delivery and translational research · 2024Article
- Immobilization of Thiol-Modified Horseradish Peroxidase on Gold Nanoparticles Enhances Enzyme Stability and Prevents Proteolytic Digestion.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Stealth and Biocompatible Gold Nanoparticles through Surface Coating with a Zwitterionic Derivative of Glutathione.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Article
- Unveiling protein corona composition: predicting with resampling embedding and machine learning.Regenerative biomaterials · 2024Article
- Single-nucleobase resolution of a surface energy transfer nanoruler forChemical science · 2023Article
- Sensing Mechanisms of Rough Plasmonic Surfaces for Protein Binding of Surface Plasmon Resonance Detection.Sensors (Basel, Switzerland) · 2023Article
- Current Status and Challenges of Analytical Methods for Evaluation of Size and Surface Modification of Nanoparticle-Based Drug Formulations.AAPS PharmSciTech · 2022Review
- Performance of nanoparticles for biomedical applications: TheBiophysics reviews · 2022Review
- Article
- Bio-Specific Au/FeBiosensors · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is demonstrated that the adsorption of bovine serum albumin (BSA) to aqueous gold colloids can be quantified with molecular resolution by differential centrifugal sedimentation (DCS). This method separates colloidal particles of comparable density by mass. When proteins adsorb to the nanoparticles, both their mass and their effective density change, which strongly affects the sedimentation time. A straightforward analysis allows quantification of the adsorbed layer. Most importantly, unlike many other methods, DCS can be used to detect chemisorbed proteins ("hard corona") as well as physisorbed proteins ("soft corona"). The results for BSA on gold colloid nanoparticles can be modeled in terms of Langmuir-type adsorption isotherms (Hill model). The effects of surface modification with small thiol-PEG ligands on protein adsorption are also demonstrated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.