Trial reportAmerican journal of hematology2017
Implementation of multidisciplinary care reduces maternal mortality in women with sickle cell disease living in low-resource setting.
Trial report in American journal of hematology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Acute pain episodes, acute chest syndrome, and pulmonary thromboembolism in pregnancy.Hematology. American Society of Hematology. Education Program · 2022Pooled it
- Interventions to reduce preterm birth and stillbirth, and improve outcomes for babies born preterm in low- and middle-income countries: A systematic review.Journal of global health · 2021Pooled it
- Comment on: Managing sickle cell disease and related complications in pregnancy: results of an international Delphi panel.BMC pregnancy and childbirth · 2026Article
- Impact of sickle cell anaemia on reproductive health: a narrative review.Reproductive health · 2025Review
- Prospective cohort study of eDiary acute pain assessments in sickle cell disease during third trimester and postpartum.Blood advances · 2025Article
- A Comparative Analysis of Haemoglobinopathy Diagnostic Techniques-The Ghanaian Picture and the Way Forward: A Narrative Review.Health science reports · 2025Review
- Patient-reported pregnancy loss and maternal complications: Insights from the sickle cell disease implementation consortium.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Article
- Screening for pulmonary hypertension in pregnant women with sickle cell disease in sub-Saharan Africa.AJOG global reports · 2024Article
- Sickle cell disease and increased adverse maternal and perinatal outcomes in different genotypes.Hematology, transfusion and cell therapy · 2024Article
- Defining global strategies to improve outcomes in sickle cell disease: a Lancet Haematology Commission.The Lancet. Haematology · 2023Review
- Pregnancy outcomes in women with sickle cell disease in California.American journal of hematology · 2023Article
- Pediatric hematology providers' contraceptive practices for female adolescents and young adults with sickle cell disease: A national survey.Pediatric blood & cancer · 2022Article
- Sustainability of low maternal mortality in pregnant women with SCD in a low-resource setting.Blood advances · 2022Article
- Indications for transfusion in the management of sickle cell disease.Hematology. American Society of Hematology. Education Program · 2021Review
- Standardizing care of those at great risk: the importance of sickle cell in pregnancy practice guidelines.British journal of haematology · 2021Article
- End points for sickle cell disease clinical trials: renal and cardiopulmonary, cure, and low-resource settings.Blood advances · 2019Article
- Complications in pregnant women with sickle cell disease.Hematology. American Society of Hematology. Education Program · 2019Review
- Identifying Clinical and Research Priorities in Sickle Cell Lung Disease. An Official American Thoracic Society Workshop Report.Annals of the American Thoracic Society · 2019Article
- A multidisciplinary approach to the clinical management of Prader-Willi syndrome.Molecular genetics & genomic medicine · 2019Article
- Multidisciplinary care results in similar maternal and perinatal mortality rates for women with and without SCD in a low-resource setting.American journal of hematology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
Abstract
Sickle cell disease (SCD) is associated with adverse pregnancy outcome. In women with SCD living in low-resource settings, pregnancy is associated with significantly increased maternal and perinatal mortality rates. We tested the hypothesis that implementing a multidisciplinary obstetric and hematology care team in a low-resource setting would significantly reduce maternal and perinatal mortality rates. We conducted a before-and-after study, at the Korle-Bu Teaching Hospital in Accra, Ghana, to evaluate the effect of a multidisciplinary obstetric-hematology care team for women with SCD in a combined SCD-Obstetric Clinic. The pre-intervention period was assessed through a retrospective chart review to identify every death and the post-intervention period was assessed prospectively. Interventions consisted of joint obstetrician and hematologist outpatient and acute inpatient reviews, close maternal and fetal surveillance, and simple protocols for management of acute chest syndrome and acute pain episodes. Primary outcomes included maternal and perinatal mortality rates before and after the study period. A total of 158 and 90 pregnant women with SCD were evaluated in the pre- and post- intervention periods, respectively. The maternal mortality rate decreased from 10 791 per 100 000 live births at pre-intervention to 1176 per 100 000 at post-intervention, representing a risk reduction of 89.1% (P = 0.007). Perinatal mortality decreased from 60.8 per 1000 total births at pre-intervention to 23.0 per 1000 at post-intervention, representing a risk reduction of 62.2% (P = 0.20). A multidisciplinary obstetric and hematology team approach can dramatically reduce maternal and perinatal mortality in a low-resource setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.