Evidence map›Paper›PMID 28512576›Full record

ReviewIUCrJ2017

Applications of contact predictions to structural biology.

Felix Simkovic, Sergey Ovchinnikov, David Baker, Daniel J Rigden

Abstract readReview
In one paragraph

Review in IUCrJ, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. State-of-the-Art and Future Directions in Structural Proteomics.Molecular & cellular proteomics : MCP · 2025
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Practical Considerations for Atomistic Structure Modeling with Cryo-EM Maps.Journal of chemical information and modeling · 2020
    Article
  7. RDbBMC bioinformatics · 2020
    Article
  8. Article
  9. Article
  10. Article
  11. Molecular replacement using structure predictions from databases.Acta crystallographica. Section D, Structural biology · 2019
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Metazoan Parasite Vaccines: Present Status and Future Prospects.Frontiers in cellular and infection microbiology · 2018
    Review
  17. Approaches to ab initio molecular replacement of α-helical transmembrane proteins.Acta crystallographica. Section D, Structural biology · 2017
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Felix SimkovicInstitute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, England.ORCID https://orcid.org/0000-0003-3430-6828
Sergey OvchinnikovDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Daniel J RigdenInstitute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, England.ORCID https://orcid.org/0000-0002-7565-8937

Funding

TRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0M
NIGMS NIH HHS T32 GM007270
6 · The paper itself

Abstract

Evolutionary pressure on residue interactions, intramolecular or intermolecular, that are important for protein structure or function can lead to covariance between the two positions. Recent methodological advances allow much more accurate contact predictions to be derived from this evolutionary covariance signal. The practical application of contact predictions has largely been confined to structural bioinformatics, yet, as this work seeks to demonstrate, the data can be of enormous value to the structural biologist working in X-ray crystallo-graphy, cryo-EM or NMR. Integrative structural bioinformatics packages such as

Indexed as

evolutionary covarianceNMR distance restraintspredicted contactsstructural bioinformaticsX-ray crystallography

Identifiers

PMID28512576
PMCPMC5414403

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.