ArticleJournal of clinical and experimental dentistry2017
The effects of three remineralizing agents on regression of white spot lesions in children: A two-week, single-blind, randomized clinical trial.
Article in Journal of clinical and experimental dentistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03656432 (Effect of CPP-ACP Pastes With/Without Fluoride on White Spot Lesion Progression, Salivary pH and Fluoride Release in High Caries Risk Patients A Randomized Clinical Trial), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of CPP-ACP Pastes With/Without Fluoride on White Spot Lesion Progression, Salivary pH and Fluoride Release in High Caries Risk Patients A Randomized Clinical Trial
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Changes in the Color and Brightness of White Spots Associated with Orthodontic Treatment 6 Months after the Application of Infiltrative Resins: Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Effectiveness of remineralizing agents in the prevention and reversal of orthodontically induced white spot lesions: a systematic review and network meta-analysis.Clinical oral investigations · 2020Pooled it
- Effect of nanohydroxyapatite paste after different pretreatment techniques on remineralization and color change of white spot lesions in children: a randomized control study.BMC oral health · 2026Trial
- Effect of remineralization after in office followed by home treatment of white spot lesions in children randomized controlled trial.Scientific reports · 2025Trial
- Remineralising efficacy of bioactive glass and casein phosphopeptide amorphous calcium phosphate in white spot lesions or early enamel caries: A systematic review of randomised controlled trials.The Japanese dental science review · 2026Review
- Comparison of the Caries Remineralizing Effects of Dentifrices Based on Natural Hydroxyapatite, Synthetic Hydroxyapatite, and Fluoride: A pH Cycling Study.Biomimetics (Basel, Switzerland) · 2026Article
- The Impact of Antimicrobial Photodynamic Therapy (aPDT) with Various Photosensitizers on the Bond Strength of Orthodontic Brackets.Journal of lasers in medical sciences · 2026Article
- Assessment of Remineralization Treatment on Primary Enamel's Microhardness and Mineral Composition Post Iron Drop Interaction.International journal of dentistry · 2026Article
- Comparative efficacy of ClinproFrontiers in oral health · 2026Article
- Does the Use of Different Remineralisation Agents in a 14-day Demineralisation/Remineralisation Cycle Affect the Bond Strength to Artificial Carious Enamel Surfaces?Oral health & preventive dentistry · 2025Article
- Efficacy of Remineralizing Agents for Prevention of Microhardness Reduction and Change in Mineral Content of Enamel in Anterior Primary Teeth after Exposure to Iron Drop.Journal of dentistry (Shiraz, Iran) · 2025Article
- White Spot Lesion Treatment Options: A Systematic Review of Different Techniques for Masking These Lesions.Gels (Basel, Switzerland) · 2025Review
- Effect of cheese and casein phosphopeptide-amorphous calcium phosphate on erosive lesions of primary teeth enamel following exposure to amoxicillin and ibuprofen syrups: AnDental research journal · 2024Article
- Assessment of the Remineralizing Potential of Biomimetic Materials on Early Artificial Caries Lesions after 28 Days: An In Vitro Study.Bioengineering (Basel, Switzerland) · 2023Article
- In vitro controlled elemental analysis to evaluate the combined effect of acidulated phosphate fluoride with Er:YAG and diode lasers.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2023Article
- An In-Vitro Comparative Study of Fluoride Varnish and Two Calcium-Containing Fluoride Products on the Remineralization of Primary Teeth Enamel.Frontiers in dentistry · 2023Article
- The effect of two calcium phosphate-containing agents on the enamel resistance of permanent molars to demineralization: An experimental study.Clinical and experimental dental research · 2022Article
- Effect of Remineralization Agents on White Spot Lesions: A Systematic Review.Journal of pharmacy & bioallied sciences · 2022Review
- Comparison of the effect of fluoride gel and two toothpastes with different materials on remineralization of initial carious lesions in primary teeth.Journal of family medicine and primary care · 2021Article
- Effectiveness of a toothpaste and a serum containing calcium silicate on protecting the enamel after interproximal reduction against demineralization.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study investigated the effect of three remineralizing agents on improving white spot lesions (WSLs). MATERIAL AND
methodsThis clinical trial included children who had at least one WSL on anterior teeth of upper or lower jaws. The participants were randomly assigned to 4 groups by treatment: 1) a cream containing casein phosphopeptide-amorphous calcium phosphate and fluoride (MI Paste Plus); 2) a cream containing hydroxyapatite and fluoride (Remin Pro); 3) a 2% sodium fluoride gel; and 4) usual home care (control). The treatment was performed for 3 times over 10 days using special trays for retaining remineralizing agents. The area and mineral content of WSLs were measured at baseline (T1) and 1 day after finishing treatment (T2). Blinding was applied for outcome assessment.
resultsEighty patients were assigned to MI Paste Plus, Remin Pro, NaF or control groups. The application of all remineralizing agents caused a significant decrease in area and a significant increase in mineral content of WSLs (
conclusionsThe in-office application of either MI Paste Plus or Remin Pro was as effective as 2% NaF for reducing area and increasing mineral content of WSLs. MI Paste Plus and Remin Pro could be recommended as suitable alternatives to NaF for managing WSLs.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.