Evidence map›Paper›PMID 28512313›Full record

ArticleScientific reports2017

A Rapid Capillary-Pressure Driven Micro-Channel to Demonstrate Newtonian Fluid Behavior of Zebrafish Blood at High Shear Rates.

Juhyun Lee, Tzu-Chieh Chou, Dongyang Kang, Hanul Kang, Junjie Chen, Kyung In Baek, Wei Wang, Yichen Ding, Dino Di Carlo, Yu-Chong Tai and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Juhyun LeeDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Tzu-Chieh ChouDepartment of Medical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.ORCID 0000-0002-6074-8286
Dongyang KangDepartment of Medical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Hanul KangDivision of Cardiology, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, 90073, USA.
Junjie ChenDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Kyung In BaekDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Wei WangDepartment of Electrical Engineering, Peking University, Beijing, 100871, China.
Yichen DingDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.ORCID 0000-0002-6242-3506
Dino Di CarloDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Yu-Chong TaiDepartment of Medical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Tzung K HsiaiDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095, USA. thsiai@mednet.ucla.edu.
California Institute of Technology · USUniversity of California, Los Angeles · USCalifornia NanoSystems Institute · USPeking University · CNVA Greater Los Angeles Healthcare System · US

Funding

Linking Spatial Variations Shear Stress-Oxidative StressR01HL083015 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HSIAI, TZUNG K · 2006 to 2015
$3.9M
Shear Stress and Light-Sheets to Study Cardiac TrabeculationR01HL129727 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K, MARSDEN, ALISON L · 2015 to 2024
$3.5M
Micro-Sensors to Study Electrical and Mechanical Coupling of Injured MyocardiumR01HL111437 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HSIAI, TZUNG K, XU, XIAOLEI · 2012 to 2020
$3.1M
NHLBI NIH HHS R01 HL083015NHLBI NIH HHS R01 HL111437NHLBI NIH HHS R01 HL129727
6 · The paper itself

Abstract

Blood viscosity provides the rheological basis to elucidate shear stress underlying developmental cardiac mechanics and physiology. Zebrafish is a high throughput model for developmental biology, forward-genetics, and drug discovery. The micro-scale posed an experimental challenge to measure blood viscosity. To address this challenge, a microfluidic viscometer driven by surface tension was developed to reduce the sample volume required (3μL) for rapid (<2 min) and continuous viscosity measurement. By fitting the power-law fluid model to the travel distance of blood through the micro-channel as a function of time and channel configuration, the experimentally acquired blood viscosity was compared with a vacuum-driven capillary viscometer at high shear rates (>500 s

Indexed as

HemodynamicsHemorheologyAnimalsBiomechanical PhenomenaBlood ViscosityMicrofluidicsReproducibility of ResultsStress, MechanicalZebrafish

Identifiers

PMID28512313
PMCPMC5434032
OpenAlexW2612974816

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.