ArticleScientific reports2017
Effects of treadmill running with different intensity on rat subchondral bone.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Animal models of critical illness in the Asia-Pacific region: current practices, shared challenges, and future directions.Intensive care medicine experimental · 2026Review
- Exercise-Dependent effects of substance P deficiency on joint degeneration and inflammation in a surgical mouse model of osteoarthritis.Arthritis research & therapy · 2025Article
- Piezo1 induces mitochondrial autophagy dysfunction leading to cartilage injury in knee osteoarthritis.Molecular medicine (Cambridge, Mass.) · 2025Article
- Decoding the impact of exercise and αCGRP signaling on murine post-traumatic osteoarthritis progression.Arthritis research & therapy · 2025Article
- Toward a clear relationship between mechanical signals and bone adaptation.Mechanobiology in medicine · 2025Review
- Gallic acid alleviates exercise-induced muscle damage by inhibiting mitochondrial oxidative stress and ferroptosis.Journal of translational medicine · 2025Article
- The mechanosensitive protein ANTXR1 is involved in maintaining cartilage homeostasis in post-traumatic osteoarthritis.Frontiers in cell and developmental biology · 2025Article
- Animal models of tendon calcification: Past, present, and future.Animal models and experimental medicine · 2024Review
- Impact of treadmill running on distal femoral cartilage thickness: a cross-sectional study of professional athletes and healthy controls.BMC sports science, medicine & rehabilitation · 2024Article
- Effect of different running protocols on bone morphology and microarchitecture of the forelimbs in a male Wistar rat model.PloS one · 2024Article
- Effects of different running intensities on the micro-level failure strain of rat femoral cortical bone structures: a finite element investigation.Biomedical engineering online · 2023Article
- Running exercise and food restriction affect bone chemical properties in young female rats.Physical activity and nutrition · 2023Article
- 3D printed-electrospun PCL/hydroxyapatite/MWCNTs scaffolds for the repair of subchondral bone.Regenerative biomaterials · 2023Article
- Relationship between altered knee kinematics and subchondral bone remodeling in a clinically translational model of ACL injury.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Establishment and identification of an animal model of long-term exercise-induced fatigue.Frontiers in endocrinology · 2022Review
- Excessive mechanical stretch‑mediated osteoblasts promote the catabolism and apoptosis of chondrocytes via the Wnt/β‑catenin signaling pathway.Molecular medicine reports · 2021Article
- Multiparametric MRI characterization of knee articular cartilage and subchondral bone shape in collegiate basketball players.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Treadmill running induces remodeling of the infrapatellar fat pad in an intensity-dependent manner.Journal of orthopaedic surgery and research · 2021Article
- Effect of Various Types of Muscle Contraction with Different Running Conditions on Mouse Humerus Morphology.Life (Basel, Switzerland) · 2021Article
- Dynamic viscoelastic characterisation of human osteochondral tissue: understanding the effect of the cartilage-bone interface.BMC musculoskeletal disorders · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subchondral bone (SB) is recognized as a key factor in normal joint protection, not only does it provide a shock absorbing and supportive function for the cartilage, but it may also be important for cartilage metabolism. Mechanical loading is considered to be a critical regulator of skeletal homeostasis, including bone and cartilage. It is suggested that both cartilage and bone may respond to mechanical loading in an intensity-dependent manner. In this report, we have discovered that the subchondral plate became thicker with higher bone mineral density (BMD) and lower porosity, while trabecular bone became more plate-like and denser with higher BMD in high-intensity running (HIR) group. Further, HIR led to highly remodeled, less mineralized, and stiffer subchondral plate and trabecular bone. On the contrary, low-intensity running and moderate-intensity running failed to result in considerable changes in microstructure, composition and hardness. Our findings suggested that running affects SB in an intensity-dependent manner. In addition, HIR may induce change in organization and composition of SB, and consequently alter its mechanical properties. HIR-induced "brittle and stiff" SB may adversely affect the overlying articular cartilage.
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