Evidence map›Paper›PMID 28512288›Full record

ArticleScientific reports2017

Lactic acid bacteria-specific induction of CD4

Linglin Fu, Jixiang Peng, Shushu Zhao, Yan Zhang, Xiurong Su, Yanbo Wang

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 71 citations in OpenAlex.

  1. Efficacy ofInternational archives of otorhinolaryngology · 2026
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  3. Impact of DietaryAnimals : an open access journal from MDPI · 2026
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  6. Therapeutic effects ofFrontiers in pharmacology · 2025
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  9. Cancers · 2024
    Article
  10. Review
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  12. Review
  13. Article
  14. Article
  15. Effects ofFoods (Basel, Switzerland) · 2023
    Article
  16. ProbioticFrontiers in nutrition · 2023
    Article
  17. The Effect of Supplementation withVeterinary sciences · 2022
    Article
  18. Review
  19. Nicotinamide Mononucleotide Combined WithFrontiers in pharmacology · 2021
    Article
  20. Shuxuening injection, derived fromPharmaceutical biology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Linglin FuFood Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, P.R. China.
Jixiang PengFood Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, P.R. China.
Shushu ZhaoFood Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, P.R. China.
Yan ZhangHebei Food Inspection and Research Institute, Shijiazhuang, 050091, P. R. China.
Xiurong SuSchool of Marine Sciences, Ningbo University, Ningbo, 315211, P.R. China.
Yanbo WangFood Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, P.R. China. wangyb@mail.zjgsu.edu.cn.
Zhejiang Gongshang University · CNHebei Food Inspection and Research Institute · CNNingbo University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The beneficial effects of probiotics have been described in allergic sensitization and diseases; however, many questions remain unanswered, such as characteristics of the most effective strains in modulation of allergic responses and how orally administered probiotics affect the systemic immune system. In the present work, oral administration of five lactic acid bacteria strains showed variable effects on protection against the allergic reaction in a mouse model of food allergy to shrimp tropomyosin (ST). The most effective anti-allergic strain, Bacillus coagulans 09.712 (Bc), greatly improved epithelial barrier function and increased lymphocytes proliferation. Moreover, Bc suppresses ST sensitization by altering Th1/Th2/Treg balance as a result of strong induction of CD4

Indexed as

AllergensAnimalsDisease Models, AnimalEpitheliumFood HypersensitivityForkhead Transcription FactorsImmunizationImmunoglobulin EImmunoglobulin GLactobacillalesLymphocyte ActivationMiceSignal TransductionT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsTOR Serine-Threonine KinasesAllergensForkhead Transcription FactorsFoxp3 protein, mouseImmunoglobulin EImmunoglobulin GTOR Serine-Threonine KinasesTropomyosin

Identifiers

PMID28512288
PMCPMC5434066
OpenAlexW2612308749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.