Evidence map›Paper›PMID 28512217›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Loss of the homologous recombination gene

Jan Gregor Botthof, Ewa Bielczyk-Maczyńska, Lauren Ferreira, Ana Cvejic

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 35 citations in OpenAlex.

  1. Meiotic Recombination in Teleosts.Advances in experimental medicine and biology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Unraveling DNA Repair Processes In Vivo: Insights from Zebrafish Studies.International journal of molecular sciences · 2023
    Review
  10. Review
  11. Learning from Zebrafish Hematopoiesis.Advances in experimental medicine and biology · 2023
    Review
  12. Article
  13. Article
  14. Loss ofBiomedicines · 2022
    Article
  15. Zebrafish models of inflammation in hematopoietic development and disease.Frontiers in cell and developmental biology · 2022
    Review
  16. RAD51: Beyond the break.Seminars in cell & developmental biology · 2021
    Review
  17. Review
  18. Article
  19. Review
  20. Zebrafish Cancer Predisposition Models.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jan Gregor BotthofDepartment of Haematology, University of Cambridge, Addenbrookes Hospital, Cambridge CB2 0XY, United Kingdom.
Ewa Bielczyk-MaczyńskaDepartment of Haematology, University of Cambridge, Addenbrookes Hospital, Cambridge CB2 0XY, United Kingdom.
Lauren FerreiraDepartment of Haematology, University of Cambridge, Addenbrookes Hospital, Cambridge CB2 0XY, United Kingdom.
Ana CvejicDepartment of Haematology, University of Cambridge, Addenbrookes Hospital, Cambridge CB2 0XY, United Kingdom; as889@cam.ac.uk.
Medical Research Council · GBNational Health Service · GBWellcome Sanger Institute · GB

Funding

Cancer Research UK 14953Cancer Research UK C45041/A14953Medical Research Council MC_PC_12009Wellcome Trust
6 · The paper itself

Abstract

RAD51 is an indispensable homologous recombination protein, necessary for strand invasion and crossing over. It has recently been designated as a Fanconi anemia (FA) gene, following the discovery of two patients carrying dominant-negative mutations. FA is a hereditary DNA-repair disorder characterized by various congenital abnormalities, progressive bone marrow failure, and cancer predisposition. In this report, we describe a viable vertebrate model of

Indexed as

AnimalsAnimals, Genetically ModifiedCytokinesDNA DamageFanconi AnemiaHematopoiesisInflammationLoss of Function MutationRad51 RecombinaseStem CellsZebrafishCytokinesRad51 Recombinasecytokine effectsFanconi anemiahematopoiesisinflammationstem cells

Identifiers

PMID28512217
PMCPMC5465903
OpenAlexW2615332104

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.