Evidence map›Paper›PMID 28512154›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2017

Glucose autoregulation is the dominant component of the hormone-independent counterregulatory response to hypoglycemia in the conscious dog.

Justin M Gregory, Noelia Rivera, Guillaume Kraft, Jason J Winnick, Ben Farmer, Eric J Allen, E Patrick Donahue, Marta S Smith, Dale S Edgerton, Phillip E Williams and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Pathophysiology and aetiology of hypoglycaemic crises.The Journal of small animal practice · 2018
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Justin M GregoryVanderbilt Ian Burr Division of Pediatric Endocrinology and Diabetes, Vanderbilt University School of Medicine, Nashville, Tennessee; justin.m.gregory.1@vanderbilt.edu.ORCID 0000-0003-2700-0062
Noelia RiveraDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee; and.
Guillaume KraftDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee; and.
Jason J WinnickDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee; and.
Ben FarmerDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee; and.
Eric J AllenDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee; and.
E Patrick DonahueDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee; and.
Marta S SmithDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee; and.
Dale S EdgertonDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee; and.
Phillip E WilliamsSection of Surgical Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee.
Alan D CherringtonDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee; and.
Vanderbilt University · US

Funding

GLUCONEOGENESIS &GLYCOGENOLYSIS:ROLE &REGULATIONR01DK018243 · NIDDK · VANDERBILT UNIVERSITY · PI Alan D Cherrington, Dale S Edgerton · 1986 to 2026
$12.2M
Pathogenesis, Targeted Therapeutics, and New Vaccines for Childhood DiseaseK12HD087023 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Michael R. DeBaun, Juan C Salazar · 2016 to 2026
$4.1M
The effect of exercise on hepatic glucose metabolism in type 2 diabetes mellitusK01DK093799 · NIDDK · VANDERBILT UNIVERSITY · PI WINNICK, JASON · 2012 to 2014
$338k
NICHD NIH HHS K12 HD087023NIDDK NIH HHS K01 DK093799NIDDK NIH HHS R01 DK018243
6 · The paper itself

Abstract

The contribution of hormone-independent counterregulatory signals in defense of insulin-induced hypoglycemia was determined in adrenalectomized, overnight-fasted conscious dogs receiving hepatic portal vein insulin infusions at a rate 20-fold basal. Either euglycemia was maintained (

Indexed as

Adipose TissueAdrenalectomyAnimalsBlood GlucoseDogsGluconeogenesisGlucoseGlucose Clamp TechniqueHomeostasisHypoglycemiaHypoglycemic AgentsInfusions, IntravenousInsulinLiverLiver GlycogenMuscle, SkeletalBlood GlucoseGlucoseHypoglycemic AgentsInsulinLiver GlycogenNorepinephrinehepatic glucose autoregulationhypoglycemiatype 1 diabetes

Identifiers

PMID28512154
PMCPMC5625082
OpenAlexW2616786125

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.