Evidence map›Paper›PMID 28512112›Full record

ArticleJournal of the American Heart Association2017

Outcome of Alcohol Septal Ablation in Mildly Symptomatic Patients With Hypertrophic Obstructive Cardiomyopathy: A Long-Term Follow-Up Study Based on the Euro-Alcohol Septal Ablation Registry.

Josef Veselka, Lothar Faber, Max Liebregts, Robert Cooper, Jaroslav Januska, Jan Krejci, Thomas Bartel, Maciej Dabrowski, Peter Riis Hansen, Vibeke Marie Almaas and 7 more

Registry-linked trialAbstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04684290 (Surgical Septal Myectomy Versus Percutaneous Transluminal Alcohol Septal Ablation in Patients With Hypertrophic Obstructive Cardiomyopathy), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04684290 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Surgical Septal Myectomy Versus Percutaneous Transluminal Alcohol Septal Ablation in Patients With Hypertrophic Obstructive Cardiomyopathy

TypeinterventionalSponsorSt. Antonius HospitalRan2021 to 2026Enrolled100ConditionsHypertrophic CardiomyopathyArmsAlcohol Septal Ablation, Surgical Septal Myectomy
3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trial
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  13. Alcohol septal ablation in hypertrophic cardiomyopathy.Global cardiology science & practice · 2018
    Review
  14. Review
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Josef VeselkaDepartment of Cardiology, 2nd Medical School, Charles University University Hospital Motol, Prague, Czech Republic veselka.josef@seznam.cz.
Lothar FaberDepartment of Cardiology, Heart and Diabetes Centre NRW, Ruhr-University Bochum, Bad Oyenhausen, Germany.
Max LiebregtsDepartment of Cardiology, St. Antonius Hospital Nieuwegein, Nieuwegein, the Netherlands.
Robert CooperInstitute of Cardiovascular Medicine and Science, Liverpool Heart and Chest Hospital, Liverpool, England.
Jaroslav JanuskaCardiocentre Podlesí, Třinec, Czech Republic.
Jan Krejci1st Department of Internal Medicine/Cardioangiology, International Clinical Research Centre, St. Anne's University Hospital and Masaryk University, Brno, Czech Republic.
Thomas BartelDepartment of Internal Medicine III, Medical University Innsbruck, Innsbruck, Austria.
Maciej DabrowskiDepartment of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland.
Peter Riis HansenDepartment of Cardiology, Gentofte Hospital, Copenhagen University Hospital, Hellerup, Denmark.
Vibeke Marie AlmaasDepartment of Cardiology, Heart and Diabetes Centre NRW, Ruhr-University Bochum, Bad Oyenhausen, Germany.
Hubert SeggewissDepartment of Internal Medicine, Schweinfurt, Germany.
Dieter HorstkotteDepartment of Cardiology, Heart and Diabetes Centre NRW, Ruhr-University Bochum, Bad Oyenhausen, Germany.
Radka AdlovaDepartment of Cardiology, 2nd Medical School, Charles University University Hospital Motol, Prague, Czech Republic.
Henning BundgaardUnit for Inherited Cardiac Diseases, Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Jurriën Ten BergDepartment of Cardiology, St. Antonius Hospital Nieuwegein, Nieuwegein, the Netherlands.
Rodney Hilton StablesInstitute of Cardiovascular Medicine and Science, Liverpool Heart and Chest Hospital, Liverpool, England.
Morten Kvistholm JensenUnit for Inherited Cardiac Diseases, Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe long-term efficacy and safety of alcohol septal ablation (ASA) in patients with highly symptomatic hypertrophic obstructive cardiomyopathy has been demonstrated. The aim of this study was to evaluate the long-term outcomes of mildly symptomatic patients with hypertrophic obstructive cardiomyopathy treated with ASA. METHODS AND

resultsWe retrospectively evaluated consecutive patients enrolled in the Euro-ASA registry (1427 patients) and identified 161 patients (53±13 years; 27% women) who were mildly symptomatic (New York Heart Association [NYHA] class II) pre-ASA. The median (interquartile range) follow-up was 4.8 (1.7-8.5) years. The clinical outcome was assessed and compared with the age- and sex-matched general population. The 30-day mortality after ASA was 0.6% and the annual all-cause mortality rate was 1.7%, which was similar to the age- and sex-matched general population (

conclusionsMildly symptomatic hypertrophic obstructive cardiomyopathy patients treated with ASA had sustained symptomatic and hemodynamic relief with a low risk of developing severe heart failure. Their survival is comparable to the general population.

Indexed as

Ablation TechniquesAdultAgedCardiomyopathy, HypertrophicEthanolEuropeFemaleHumansKaplan-Meier EstimateLongitudinal StudiesMaleMiddle AgedProportional Hazards ModelsRecovery of FunctionRegistriesRetrospective StudiesEthanolablationhypertrophic cardiomyopathyoutcome

Identifiers

PMID28512112
PMCPMC5524107

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.