ArticleJournal of neuroscience methods2017
3D printing and modelling of customized implants and surgical guides for non-human primates.
Article in Journal of neuroscience methods, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 110 citations in OpenAlex.
- Enhanced construct stability with a locking plate system integrated into 3D-printed titanium implants for bone defect reconstruction: a biomechanical comparison of locking versus nonlocking screw fixation.Journal of orthopaedic surgery and research · 2026Article
- Stereotactic lesioning of cholinergic cells by injection of ME20.4 Saporin in the nucleus basalis of Meynert in a rhesus monkey (Macaca mulatta).Journal of neuropathology and experimental neurology · 2026Article
- Customizable artificial simulator for developing, planning, and training personnel on neurophysiology and surgical procedures in non-human primates.Journal of neuroscience methods · 2025Article
- Volumetric mesoscopic electrophysiology: a new imaging modality for the nonhuman primate.Journal of neurophysiology · 2025Article
- Encoding of cerebellar dentate neuron activity during visual attention in rhesus macaques.eLife · 2025Article
- A 3D-Printed helmet for precise and repeatable neuromodulation targeting in awake non-human primates.Heliyon · 2024Article
- A Neural Implant Design Toolbox for Nonhuman Primates.Journal of visualized experiments : JoVE · 2024Article
- An Ultraflexible Electrode Array for Large-Scale Chronic Recording in the Nonhuman Primate Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Use of 3D Printing Techniques to Fabricate Implantable Microelectrodes for Electrochemical Detection of Biomarkers in the Early Diagnosis of Cardiovascular and Neurodegenerative Diseases.ACS measurement science au · 2023Review
- Chronic stability of a neuroprosthesis comprising multiple adjacent Utah arrays in monkeys.Journal of neural engineering · 2023Article
- Trends and Treatment Approaches for Complications in Neuroscience Experiments with Monkey Species.Comparative medicine · 2023Article
- Inversion of pop-out for a distracting feature dimension in monkey visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Multi-area recordings and optogenetics in the awake, behaving marmoset.Nature communications · 2023Article
- Comparison of 2 open-sourced 3-dimensional modeling techniques for orthopaedic application.OTA international : the open access journal of orthopaedic trauma · 2022Article
- Additively manufactured metallic biomaterials.Bioactive materials · 2022Review
- 1024-channel electrophysiological recordings in macaque V1 and V4 during resting state.Scientific data · 2022Article
- A neuronal basis of iconic memory in macaque primary visual cortex.Current biology : CB · 2021Article
- A Review on Development of Bio-Inspired Implants Using 3D Printing.Biomimetics (Basel, Switzerland) · 2021Review
- Article
- Bone formation with functionalized 3D printed poly-ε-caprolactone scaffold with plasma-rich-fibrin implanted in critical-sized calvaria defect of rat.Journal of dental sciences · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPrimate neurobiologists use chronically implanted devices such as pedestals for head stabilization and chambers to gain access to the brain and study its activity. Such implants are skull-mounted, and made from a hard, durable material, such as titanium. NEW
methodHere, we present a low-cost method of creating customized 3D-printed cranial implants that are tailored to the anatomy of individual animals. We performed pre-surgical computed tomography (CT) and magnetic resonance (MR) scans to generate three-dimensional (3D) models of the skull and brain. We then used 3D modelling software to design implantable head posts, chambers, and a pedestal anchorage base, as well as craniotomy guides to aid us during surgery. Prototypes were made from plastic or resin, while implants were 3D-printed in titanium. The implants underwent post-processing and received a coating of osteocompatible material to promote bone integration.
resultsTheir tailored fit greatly facilitated surgical implantation, and eliminated the gap between the implant and the bone. To date, our implants remain robust and well-integrated with the skull. COMPARISON WITH EXISTING METHOD(S): Commercial-off-the-shelf solutions typically come with a uniform, flat base, preventing them from sitting flush against the curved surface of the skull. This leaves gaps for fluid and tissue ingress, increasing the risk of microbial infection and tissue inflammation, as well as implant loss.
conclusionsThe use of 3D printing technology enabled us to quickly and affordably create unique, complex designs, avoiding the constraints levied by traditional production methods, thereby boosting experimental success and improving the wellbeing of the animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.