ArticleJournal of ovarian research2017
What we learned from extended culture of 'rejected' day-3 cleavage stage embryos: a prospective cohort study.
Article in Journal of ovarian research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- The ART of Embryo Selection: A Review of Methods to Rank the Most Competent Embryo(s) for Transfer to Optimize IVF Success.Biomedicines · 2025Review
- Single frozen-thawed blastocyst derived from poor-grade Day 3 embryo is not associated with adverse neonatal outcomes: a retrospective cohort study.Archives of gynecology and obstetrics · 2025Article
- Effect of blastomere cell number on ART outcome of fresh single day 3 embryo transfer.BMC pregnancy and childbirth · 2024Article
- Disposition of embryos from women who only produced morphologically poor embryos on day three.Biomedical journal · 2022Observational
- Embryo blastulation and quality between days 5 and 6 of extended embryo culture.Journal of assisted reproduction and genetics · 2021Observational
- Miscarriage Rate Is High With Frozen-Thawed Blastocysts Arising From Poor-Quality Cleavage Stage Embryos.Frontiers in endocrinology · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo test whether poor quality day-3 embryos can undergo successful blastulation and implantation.
methodsA prospective cohort study was conducted. Whether or not a good quality embryo was transferred on day-3, poor quality (rejected) embryos were further cultured and followed. The clinical outcome of each embryo was assessed.
resultsA total of 694 rejected embryos (from 205 patients) were included, with a blastulation rate of 21.2% (147 embryos) compared to 64.2% general blastulation rate reported by our laboratory (P < 0.01). In a multivariate logistic regression model, only their grade on day-3 significantly affected blastulation (P = 0.01). A total of 97 embryos attained eligibility for fresh transfer or cryopreservation, only 6 of which resulted from a day-3 embryo scored < 2. Of these, 52 were transferred, resulting in 21 pregnancies (16 clinical and 5 chemical). In summary, 694 cultured embryos yielded 16 clinical pregnancies; a 2.3% clinical pregnancy rate.
conclusionsLow score day-3 embryos can result in successful blastulation and clinical pregnancies. However, the normal blastulation rate is poor.
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