ArticleBMC neurology2017
Mindfulness-based stress reduction for people with multiple sclerosis - a feasibility randomised controlled trial.
Article in BMC neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02136485 (Mindfulness-based Stress Reduction in Multiple Sclerosis - a Randomised Controlled Trial), which is not on this map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mindfulness-based Stress Reduction in Multiple Sclerosis - a Randomised Controlled Trial
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Effects of mindfulness-based interventions on cognition in people with multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials.Frontiers in psychiatry · 2024Pooled it
- Feasibility, Acceptability, and Efficacy of Mindfulness Training in People With Upper Motor Neuron Disorders: A Systematic Review.Archives of physical medicine and rehabilitation · 2022Pooled it
- Which exercise and behavioural interventions show most promise for treating fatigue in multiple sclerosis? A network meta-analysis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021Pooled it
- Pooled it
- Transdiagnostic treatment of emotional disorders in people with multiple sclerosis: randomized controlled trial.BMC psychology · 2020Trial
- Impact of mindfulness-based stress reduction for people with multiple sclerosis at 8 weeks and 12 months: A randomized clinical trial.Multiple sclerosis (Houndmills, Basingstoke, England) · 2019Trial
- Experiences of a Mindfulness-Based Telehealth Program Modified for Adults with Cerebral Palsy-A Qualitative Study.Healthcare (Basel, Switzerland) · 2026Article
- Eating Disorder Symptoms in Multiple Sclerosis: Relationships Between Neuroticism, Body Dissatisfaction, and Self-Esteem.Nutrients · 2025Article
- Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- The Effect of Mindset and Breathing Exercises on Physical and Mental Health in Persons with Spinal Cord Injury-A Pilot Feasibility Study.International journal of environmental research and public health · 2023Article
- Conceptualization, use, and outcomes associated with compassion in the care of people with multiple sclerosis: a scoping review.Journal of neurology · 2023Article
- The HEADS: UP Development Study: Working with Key Stakeholders to Adapt a Mindfulness-Based Stress Reduction Course for People with Anxiety and Depression after Stroke.Healthcare (Basel, Switzerland) · 2023Article
- The Effect of Meditation-Based Interventions on Patients with Fatigue Symptoms: A Systematic Review and Meta-Analysis.Psychologica Belgica · 2023Article
- Mindfulness-integrated cognitive behavioral therapy: Is it effective on stress coping strategies in women with multiple sclerosis?Caspian journal of internal medicine · 2022Article
- A Hybrid Approach for MS Diagnosis Through Nonlinear EEG Descriptors and Metaheuristic Optimized Classification Learning.Computational intelligence and neuroscience · 2022Article
- Mindfulness training during brief periods of hospitalization in multiple sclerosis (MS): beneficial alterations in fatigue and the mediating role of depression.BMC neurology · 2021Article
- Grieving a disrupted biography: an interpretative phenomenological analysis exploring barriers to the use of mindfulness after neurological injury or impairment.BMC psychology · 2021Article
- The influence of trait mindfulness on depression in multiple sclerosis: potential implications for treatment.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
- Behavioral Interventions in Multiple Sclerosis.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2020Article
- Review of Two Popular Eating Plans within the Multiple Sclerosis Community: Low Saturated Fat and Modified Paleolithic.Nutrients · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple sclerosis (MS) is a stressful condition. Mental health comorbidity is common. Stress can increase the risk of depression, reduce quality of life (QOL), and possibly exacerbate disease activity in MS. Mindfulness-Based Stress Reduction (MBSR) may help, but has been little studied in MS, particularly among more disabled individuals.
methodsThe objective of this study was to test the feasibility and likely effectiveness of a standard MBSR course for people with MS. Participant eligibility included: age > 18, any type of MS, an Expanded Disability Status Scale (EDSS) </= 7.0. Participants received either MBSR or wait-list control. Outcome measures were collected at baseline, post-intervention, and three-months later. Primary outcomes were perceived stress and QOL. Secondary outcomes were common MS symptoms, mindfulness, and self-compassion.
resultsFifty participants were recruited and randomised (25 per group). Trial retention and outcome measure completion rates were 90% at post-intervention, and 88% at 3 months. Sixty percent of participants completed the course. Immediately post-MBSR, perceived stress improved with a large effect size (ES 0.93; p < 0.01), compared to very small beneficial effects on QOL (ES 0.17; p = 0.48). Depression (ES 1.35; p < 0.05), positive affect (ES 0.87; p = 0.13), anxiety (ES 0.85; p = 0.05), and self-compassion (ES 0.80; p < 0.01) also improved with large effect sizes. At three-months post-MBSR (study endpoint) improvements in perceived stress were diminished to a small effect size (ES 0.26; p = 0.39), were negligible for QOL (ES 0.08; p = 0.71), but were large for mindfulness (ES 1.13; p < 0.001), positive affect (ES 0.90; p = 0.54), self-compassion (ES 0.83; p < 0.05), anxiety (ES 0.82; p = 0.15), and prospective memory (ES 0.81; p < 0.05).
conclusionsRecruitment, retention, and data collection demonstrate that a RCT of MBSR is feasible for people with MS. Trends towards improved outcomes suggest that a larger definitive RCT may be warranted. However, optimisation changes may be required to render more stable the beneficial treatment effects on stress and depression.
trial registrationClinicalTrials.gov Identifier NCT02136485 ; trial registered 1st May 2014.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.