ArticleMalaria journal2017
Antiplasmodial activity of Indigofera spicata root extract against Plasmodium berghei infection in mice.
Article in Malaria journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Antiplasmodial, antimalarial activities and toxicity of African medicinal plants: a systematic review of literature.Malaria journal · 2021Pooled it
- Medicinal plants used in traditional treatment of malaria in Ethiopia: a review of ethnomedicine, anti-malarial and toxicity studies.Malaria journal · 2022Review
- Antimalarial Activity of Crude Extract and Solvent Fractions of Leaves ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Antiplasmodial Activity of 80% Methanolic Extract and Solvent Fractions of Stem Bark ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Evaluation of the Antimalarial Activity of the Leaf Latex ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Antimalarial Activity of Methanolic Extracts and Solvent Fractions ofJournal of experimental pharmacology · 2021Article
- Article
- Studies on Activities and Chemical Characterization of Medicinal Plants in Search for New Antimalarials: A Ten Year Review on Ethnopharmacology.Frontiers in pharmacology · 2021Review
- Antimalarial Activity of the Leaf Latex ofJournal of tropical medicine · 2020Article
- Antimalarial Activity ofJournal of experimental pharmacology · 2020Article
- Anti-malarial activity of the root extract of Euphorbia abyssinica (Euphorbiaceae) against Plasmodium berghei infection in mice.Malaria journal · 2019Article
- Antimalarial Activity ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Antimalarial Activity and Toxicological Assessment ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Antiplasmodial activity of two medicinal plants against clinical isolates ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn addition to pharmacovigilance and pharmaco-economic concerns, resistance to anti-malarial medicines has been documented in all classes of anti-malarials and this is further worsened by resistance to common insecticides by malaria vector, which is a major threat to malaria control. As a means of facing the challenges of searching for new anti-malarial agents, the current study focused on evaluation of anti-malarial activity of root extract of Indigofera spicata.
methodsChloroquine-sensitive rodent malaria parasite, Plasmodium berghei (ANKA strain) was used to infect the Swiss Albino mice in 4-day suppressive and curative models. The crude hydromethanolic root extract of I. spicata at 200, 400 and 600 mg/kg doses was administered to a group of five mice. Important parameters, such as level of parasitaemia, packed cell volume (PCV), survival time, and body weight were determined and the significance of the differences between mean values of the five groups was analysed by one-way ANOVA followed by post hoc Tukey's Multiple Comparison test.
resultsIn both the suppressive and curative models, 400 and 600 mg/kg doses of the extract suppressed the level of parasitaemia significantly (p < 0.001) compared to the vehicle-treated groups, 34.93 and 53.42%, respectively. However, only the mice which were treated with the 600 mg/kg dose of the extract had significant difference in their mean survival time. In other parameters, namely PCV and mean body weight, there was no statistically significant difference between the extract-treated groups when compared to the negative control.
conclusionsThis study revealed that the root extract of I. spicata possesses anti-malarial activity and necessitates further scientific validation.
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