Evidence map›Paper›PMID 28511457›Full record

ArticleJournal of clinical and diagnostic research : JCDR2017

Leptin as a Predictive Marker in Unexplained Infertility in North Indian Population.

Pratibha Kumari, S P Jaiswar, Pushplata Shankhwar, Sujata Deo, Kalim Ahmad, Bushra Iqbal, A A Mahdi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and diagnostic research : JCDR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. High-Fat Diets Disturb Rat Epididymal Sperm Maturation.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Pratibha KumariPhD Scolar, Department of Obstetrics and Gynaecology, KGMU, Lucknow, Uttar Pradesh, India.
S P JaiswarProfessor, Department of Obstetrics and Gynaecology, KGMU, Lucknow, Uttar Pradesh, India.
Pushplata ShankhwarProfessor, Department of Obstetrics and Gynaecology, KGMU, Lucknow, Uttar Pradesh, India.
Sujata DeoProfessor, Department of Obstetrics and Gynaecology, KGMU, Lucknow, Uttar Pradesh, India.
Kalim AhmadProfessor, Department of Biochemistry, KGMU, Lucknow, Uttar Pradesh, India.
Bushra IqbalPhD Scolar, Department of Physiology, KGMU, Lucknow, Uttar Pradesh, India.
A A MahdiProfessor, Department of Biochemistry, KGMU, Lucknow, Uttar Pradesh, India.
Government of Uttar Pradesh · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAccording to WHO, the primary infertility in India is about 3.9% (age-standardized to 25-49 year) and 16.8% (age-standardized to 15-49 year), using the "age but no birth" definition. Several factors which affect fertility include low sperm production in men, poor egg quality and blocked fallopian tubes in women and also hormonal imbalances. Leptin plays a critical role in women's reproduction and neuroendocrine health. It is used for treating exercise-induced bone loss, eating disorders and infertility.

aimTo evaluate the serum leptin levels in Indians and to ascertain the relationship between serum leptin levels, Unexplained Infertility (UI) and related variables [height, weight, Waist Hip Ratio (WHR), Body Mass Index (BMI)] between obese infertile, non-obese infertile and healthy subjects. MATERIALS AND

methodsThe present case-control study was conducted at the Department of Obstetrics and Gynaecology, King George's Medical University (KGMU), Lucknow, India and funded by Department of Science and Technology, New Delhi, India. The study included 229 female participants in the age group of 18-40 years (120 cases and 109 controls) who were randomly selected. The blood samples were collected from the Infertility Clinic, Queen Mary's Hospital, KGMU, Lucknow, India. All the participants underwent complete physical examination. Initially, the participants were categorized into fertile and infertile groups, they were further divided on the basis of BMI, normal (BMI- 18.5-24.5) and overweight or obese (BMI≥25). Leptin level was measured by Active Human Leptin ELISA kit and BMI of all subjects was calculated in kg/m

resultsA highly positive linear correlation (R=0.754, p<0.001) was found between BMI and serum leptin in unexplained infertile women, which indicates a strong relationship between BMI and serum leptin. The variation in serum leptin is explained by the independent variable, BMI. There was a partial positive linear correlation between BMI and serum leptin in the control group. Statistically there was no significant correlation (R=0.109, p=0.258) between BMI and serum leptin in the control group.

conclusionThe present study clearly demonstrates that level of leptin is higher in unexplained infertile than in the fertile group, and also shows that a strong relationship exists between BMI and serum leptin in the obese group. Serum leptin level was significantly higher in obese than non-obese subjects. Thus, leptin is an important factor for normal reproductive function. Obesity, the main cause of infertility may be controlled by regulating the leptin concentration.

Indexed as

Body mass indexNeuroendocrineObesityReproductionSerum leptinUnexplained infertility

Identifiers

PMID28511457
PMCPMC5427383
OpenAlexW2607333905

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.