Evidence map›Paper›PMID 28511261›Full record

ReviewSeminars in neurology2017

Current Practice and the Future of Deep Brain Stimulation Therapy in Parkinson's Disease.

Leonardo Almeida, Wissam Deeb, Chauncey Spears, Enrico Opri, Rene Molina, Daniel Martinez-Ramirez, Aysegul Gunduz, Christopher W Hess, Michael S Okun

Abstract readReview
In one paragraph

Review in Seminars in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Investigating the effect of STN-DBS stimulation and different frequency settings on the acoustic-articulatory features of vowels.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Leonardo AlmeidaDepartment of Neurology, University of Florida, Center for Movement Disorders and Neurorestoration, Gainesville, Florida.
Wissam DeebDepartment of Neurology, University of Florida, Center for Movement Disorders and Neurorestoration, Gainesville, Florida.
Chauncey SpearsDepartment of Neurology, University of Florida, Center for Movement Disorders and Neurorestoration, Gainesville, Florida.
Enrico OpriBiomedical Engineering, University of Florida, Gainesville, Florida.
Rene MolinaBiomedical Engineering, University of Florida, Gainesville, Florida.
Daniel Martinez-RamirezDepartment of Neurology, University of Florida, Center for Movement Disorders and Neurorestoration, Gainesville, Florida.
Aysegul GunduzBiomedical Engineering, University of Florida, Gainesville, Florida.
Christopher W HessDepartment of Neurology, University of Florida, Center for Movement Disorders and Neurorestoration, Gainesville, Florida.
Michael S OkunDepartment of Neurology, University of Florida, Center for Movement Disorders and Neurorestoration, Gainesville, Florida.
University of Florida · US

Funding

Together: Transforming and Translating Discovery to Improve HealthKL2TR001429 · NCATS · UNIVERSITY OF FLORIDA · PI GUIRGIS, FAHEEM W, LEEUWENBURGH, CHRISTIAAN · 2015 to 2023
$5.5M
Together: Transforming and Translating Discovery to Improve HealthTL1TR001428 · NCATS · UNIVERSITY OF FLORIDA · PI MCCORMACK, WAYNE T. · 2015 to 2023
$3.9M
Mobile Decision Support System for Nurse Management of Neuromodulation TherapyR01NR014852 · NINR · UNIVERSITY OF UTAH · PI BUTSON, CHRISTOPHER R, OKUN, MICHAEL S · 2015 to 2019
$2.9M
NCATS NIH HHS KL2 TR001429NCATS NIH HHS TL1 TR001428NINR NIH HHS R01 NR014852
6 · The paper itself

Abstract

Deep brain stimulation (DBS) is an effective therapy for Parkinson's disease patients experiencing motor fluctuations, medication-resistant tremor, and/or dyskinesia. Currently, the subthalamic nucleus and the globus pallidus internus are the two most widely used targets, with individual advantages and disadvantages influencing patient selection. Potential DBS patients are selected using the few existing guidelines and the available DBS literature, and many centers employ an interdisciplinary team review of the individual's risk-benefit profile. Programmed settings vary based on institution- or physician-specific protocols designed to maximize benefits and limit adverse effects. Expectations should be realistic and clearly defined during the evaluation process, and each bothersome symptom should be addressed in the context of building the risk-benefit profile. Current DBS research is focused on improved symptom control, the development of newer technologies, and the improved efficiency of stimulation delivery. Techniques deliver stimulation in a more personalized way, and methods of adaptive DBS such as closed-loop approaches are already on the horizon.

Indexed as

Deep Brain StimulationGlobus PallidusHumansParkinson DiseaseSubthalamic NucleusTreatment Outcome

Identifiers

PMID28511261
PMCPMC6195220
OpenAlexW2614225508

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.