ArticleBotanical studies2014
Folium Sennae protects against hydroxyl radical-induced DNA damage via antioxidant mechanism: an in vitro study.
Article in Botanical studies, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A Review on Bioactive Anthraquinone and Derivatives as the Regulators for ROS.Molecules (Basel, Switzerland) · 2023Review
- Effects of different boiling processes on chemical compositions ofFrontiers in nutrition · 2022Article
- Antioxidant and Cytoprotective Effects of Kukoamines A and B: Comparison and Positional Isomeric Effect.Molecules (Basel, Switzerland) · 2018Article
- Protective Effects of Dihydromyricetin against •OH-Induced Mesenchymal Stem Cells Damage and Mechanistic Chemistry.Molecules (Basel, Switzerland) · 2016Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the study, Folium Sennae (FS) was firstly extracted by various solvents to obtain five FS extracts. Then, five FS extracts were evaluated for the protective effects against •OH-induced DNA damage, antioxidant abilities in vitro, and chemical contents using various methods. On this basis, the correlation graphs between the pharmacological effects and chemical contents were plotted to obtain the correlation coefficients (R values). Finally, in order to obtain biological evidence, ethyl acetate extract of FS (EAFS) was investigated for the protective effect against •OH-induced MSCs (mesenchymal stem cells) damage using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl) assay.
resultsThe pharmacological assays indicated that five FS extracts could effectively protect against •OH-induced DNA damage. The correlation analysis suggested that the average R values of total phenolics, total anthraquinones, aloe-emodin, rhein, and emodin were respectively 0.843, 0.833, 0.753, 0.820, and 0.784, while those of total sugars and total saponins were respectively 0.103 and 0.0068. The mechanistic analysis revealed that five FS extracts could also scavenge •OH, •O
conclusionOn this basis, it can be concluded that: (i) Folium Sennae exhibits a protective effect against •OH-induced damages to DNA and MSCs; (ii ) The effects may be attributed to phytophenols (especially aloe-emodin, rhein, and emodin), not sugars or saponins; (iii) They exert the protective action via hydrogen atom transfer (HAT) and/or sequential electron proton transfer (SEPT) mechanisms which make phenolic -OH moiety be oxidized to stable semi-quinone form; (iv) The stability of semi-quinone form can ultimately be responsible for the protective or antioxidant effect of phytophenols.
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