ArticleBrain topography2017
Zoomed MRI Guided by Combined EEG/MEG Source Analysis: A Multimodal Approach for Optimizing Presurgical Epilepsy Work-up and its Application in a Multi-focal Epilepsy Patient Case Study.
Article in Brain topography, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Variation in Reported Human Head Tissue Electrical Conductivity Values.Brain topography · 2019Pooled it
- Group optimization methods for dose planning in tES.Journal of neural engineering · 2025Article
- Respiratory modulations of cortical excitability and interictal spike timing in focal epilepsy: a case report.Communications medicine · 2025Article
- How to assess the accuracy of volume conduction models? A validation study with stereotactic EEG data.Frontiers in human neuroscience · 2024Article
- Bioelectromagnetism in Human Brain Research: New Applications, New Questions.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2023Review
- Validating EEG source imaging using intracranial electrical stimulation.Brain communications · 2023Article
- Hippocampal dentate gyrus integrity revealed with ultrahigh resolution diffusion imaging predicts memory performance in older adults.Hippocampus · 2022Article
- Black Line Sign in Focal Cortical Dysplasia IIB: A 7T MRI and Electroclinicopathologic Study.Neurology · 2022Article
- Validating EEG, MEG and Combined MEG and EEG Beamforming for an Estimation of the Epileptogenic Zone in Focal Cortical Dysplasia.Brain sciences · 2022Article
- A comprehensive study on electroencephalography and magnetoencephalography sensitivity to cortical and subcortical sources.Human brain mapping · 2021Article
- The effect of stimulation type, head modeling, and combined EEG and MEG on the source reconstruction of the somatosensory P20/N20 component.Human brain mapping · 2019Article
- Changing concepts in presurgical assessment for epilepsy surgery.Nature reviews. Neurology · 2019Review
- Functional brain mapping: overview of techniques and their application to neurosurgery.Neurosurgical review · 2019Review
- Parallel Transmission for Ultrahigh Field MRI.Topics in magnetic resonance imaging : TMRI · 2019Review
- Evidence for the Role of Magnetic Source Imaging in the Presurgical Evaluation of Refractory Epilepsy Patients.Frontiers in neurology · 2019Review
- The FieldTrip-SimBio pipeline for EEG forward solutions.Biomedical engineering online · 2018Article
- The Discontinuous Galerkin Finite Element Method for Solving the MEG and the Combined MEG/EEG Forward Problem.Frontiers in neuroscience · 2018Article
- The Effect of Head Model Simplification on Beamformer Source Localization.Frontiers in neuroscience · 2017Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, the use of source analysis based on electroencephalography (EEG) and magnetoencephalography (MEG) has gained considerable attention in presurgical epilepsy diagnosis. However, in many cases the source analysis alone is not used to tailor surgery unless the findings are confirmed by lesions, such as, e.g., cortical malformations in MRI. For many patients, the histology of tissue resected from MRI negative epilepsy shows small lesions, which indicates the need for more sensitive MR sequences. In this paper, we describe a technique to maximize the synergy between combined EEG/MEG (EMEG) source analysis and high resolution MRI. The procedure has three main steps: (1) construction of a detailed and calibrated finite element head model that considers the variation of individual skull conductivities and white matter anisotropy, (2) EMEG source analysis performed on averaged interictal epileptic discharges (IED), (3) high resolution (0.5 mm) zoomed MR imaging, limited to small areas centered at the EMEG source locations. The proposed new diagnosis procedure was then applied in a particularly challenging case of an epilepsy patient: EMEG analysis at the peak of the IED coincided with a right frontal focal cortical dysplasia (FCD), which had been detected at standard 1 mm resolution MRI. Of higher interest, zoomed MR imaging (applying parallel transmission, 'ZOOMit') guided by EMEG at the spike onset revealed a second, fairly subtle, FCD in the left fronto-central region. The evaluation revealed that this second FCD, which had not been detectable with standard 1 mm resolution, was the trigger of the seizures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.