ArticleBotanical studies2013
Enhanced synthesis of andrographolide by Aspergillus niger and Penicillium expansum elicitors in cell suspension culture of Andrographis paniculata (Burm. f.) Nees.
Article in Botanical studies, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Evaluation of Salicylic Acid and Methyl Jasmonate as Elicitors inMolecules (Basel, Switzerland) · 2023Article
- Manipulation of DXP pathway for andrographolide production in callus cultures of Andrographis paniculata.Planta · 2021Article
- Salicylic acid-enhanced biosynthesis of pharmacologically important lignans and neo lignans in cell suspension culture ofEngineering in life sciences · 2019Article
- Piriformospora indica promotes the growth of the in-vitro-raised Cymbidium aloifolium plantlet and their acclimatization.Plant signaling & behavior · 2019Article
- Anti-cancer labdane diterpenoids from adventitious roots of Andrographis paniculata: augmentation of production prospect endowed with pathway gene expression.Protoplasma · 2018Article
- In vitro elicitation, isolation, and characterization of conessine biomolecule from Holarrhena antidysenterica (L.) Wall. callus and its larvicidal activity against malaria vector, Anopheles stephensi Liston.Environmental science and pollution research international · 2018Article
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2 authors.
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Abstract
backgroundAndrographis paniculata (Burm. f.) Nees is an important medicinal plant which has enormous applications in pharmaceutical industries. Cell suspension culture of Andrographis paniculata (Burm. f.) Nees. was treated with Aspergillus niger and Penicillium expansum elicitors to enhance the synthesis of andrographolide, the bioactive constituent of A. paniculata.
resultThe elicitation treatment with fungal elicitors (A. niger and P. expansum) was observed to be most suitable for eliciting andrographolide production in the culture. The quantification of andrographolide was done using High Performance Liquid Chromatography (HPLC) technique. A. niger extract (1.5 ml with10 days treatment duration) revealed 6.94 fold increase in andrographolide content (132 μg) which was higher than the control (19 μg). P. expansum elicitor (0.6% with 8 days treatment duration) could reveal 6.23 fold enhancement in andrographolide content (81.0 μg) over control (13 μg).
conclusionThe results obtained reveal that the longer treatment duration is most favorable for the elicitation of andrographolide using both the fungal elicitors.
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