SynthesisJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2017
A Systematic Review of Proinsulin-Secreting Pancreatic Neuroendocrine Tumors.
Synthesis in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Insulin Resistance Modifies the Effects of Omega-3 Acid Ethyl Esters on Left Ventricular Remodeling After Acute Myocardial Infarction (from the OMEGA-REMODEL Randomized Clinical Trial).The American journal of cardiology · 2020Trial
- Metastatic proinsulin-secreting tumor: a rare cause of persistent hypoglycemia.JCEM case reports · 2026Article
- Early prediction of metastatic insulinoma using tumor size and biochemical markers: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Proinsulinoma Unmasked by Intermittent Fasting: A Case of Endogenous Proinsulinaemic Hypoglycaemia.Case reports in endocrinology · 2026Article
- Insulinoma: Metastatic Recurrence 38 Years Following Initial Diagnosis in Pregnancy.JCEM case reports · 2024Article
- Investigation and Causes of Spontaneous (Non-Diabetic) Hypoglycaemia in Adults: Pitfalls to Avoid.Diagnostics (Basel, Switzerland) · 2023Review
- A Novel Somatic Mutation Implicates ATP6V0D1 in Proinsulin Processing.Journal of the Endocrine Society · 2023Article
- Intraoperative selective arterial calcium injection test to confirm complete resection of a proinsulinoma.Journal of surgical case reports · 2022Article
- Effect of the transcription factor YY1 on the development of pancreatic endocrine and exocrine tumors: a narrative review.Cell & bioscience · 2021Review
- The functioning side of the pancreas: a review on insulinomas.Journal of endocrinological investigation · 2020Review
- Primary Functioning Neuroendocrine Tumor of the Appendix with Hypoglycemia Syndrome: A Case Report and Review of Neuroendocrine Tumors.The Permanente journal · 2020Article
- Proinsulin-Secreting Neuroendocrine Tumors of the Pancreas: A Single-Centre Experience.Gastrointestinal tumors · 2019Article
- Recurrence of Metastatic Pro-insulinoma Nearly 50 Years After Subtotal Pancreatectomy.Journal of gastrointestinal cancer · 2019Article
- Refractory spontaneous hypoglycaemia: a diagnostic conundrumEndocrinology, diabetes & metabolism case reports · 2018Article
- USE OF A CONTINUOUS GLUCOSE MONITOR FOR PREOPERATIVE MONITORING AND TREATMENT OF HYPOGLYCEMIA IN A CASE OF PANCREATIC NEUROENDOCRINE TUMOR.AACE clinical case reportsArticle
- PROINSULIN-PREDOMINANT PANCREATIC NEUROENDOCRINE TUMOR-INDUCED HYPOGLYCEMIA AFTER ROUX-EN-Y GASTRIC BYPASS SURGERY.AACE clinical case reportsArticle
- Metastatic Insulinoma Presenting With Postprandial Hypoglycemia.AACE clinical case reportsArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPancreatic neuroendocrine tumors (PNETs) are a heterogeneous group of islet cell-derived neoplasms with a propensity toward hormone production. Among PNETs, proinsulin-secreting tumors (proinsulinomas) are exceedingly rare. The objective of this study is to collect and summarize the existing literature to provide a comprehensive evaluation of this uncommon disease.
methodsA systematic review was performed to characterize the clinicopathologic features of proinsulinoma. Using the electronic biomedical databases PubMed, Ovid Medline, and Embase, 316 publications were screened for relevance of which 14 were selected. We also present two patients with proinsulinoma treated at Yale New Haven Hospital.
resultsOf the 16 patients included in the study, the mean age was 56.8 and there was a 2:1 female predominance. The majority of patients presented with symptomatic hypoglycemia with normal or low insulin levels. Median tumor diameter was 1.2 cm and 80% were located in the body and tail of the pancreas. Following resection, most patients had normalization of hormonal levels without recurrence (75%; 12/16).
conclusionProinsulinomas are rare pancreatic neuroendocrine tumors that have the potential to cause hypoglycemia. While insulinomas and proinsulin-secreting tumors have many physiologic parallels, these cases illustrate several key distinctions in their diagnosis and management.
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