ArticleNucleic acids research2017
Phosphorylation of the transcriptional repressor MYB15 by mitogen-activated protein kinase 6 is required for freezing tolerance in Arabidopsis.
Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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Who cites it
87 citing papers in PubMed, 214 citations in OpenAlex.
- MaMPK3-2 Phosphorylating and Stabilizing Transcriptional Repressor MaAS1 by Counteracting MaRNF4-Mediated Ubiquitination During Banana Fruit Ripening.Plant biotechnology journal · 2026Article
- MPK3-mediated phosphorylation inactivates MYB4 to promote FIT-dependent iron acquisition.EMBO reports · 2026Article
- SlBBX19 modulates plant development and negatively regulates chilling tolerance in tomato.The Plant journal : for cell and molecular biology · 2026Article
- MYB Factors: Hubs of Plant Stress and Hormone Crosstalk.Plant biotechnology journal · 2026Review
- Identification of the R2R3-MYB gene family in wild jujube (Ziziphus jujuba var. spinosa) and analysis of its expression under drought stress.BMC plant biology · 2026Article
- LsMAPK6 Phosphorylates the LsCO Protein to Enhance Its Stability and Transcriptional Activity, Promoting Floral Transition Upon High Temperatures in Lettuce.Plant biotechnology journal · 2026Article
- Cold-responsive interaction between MdRAD23D1 and MdMYB15 confers cold stress tolerance via the CBF pathway in apple (Malus domestica).PLoS genetics · 2026Article
- TaWRKY115 enhances cold tolerance by weakening the expression of TaMYB4 on CBFs in common wheat.National science review · 2026Article
- Haplotype-resolved genome assembly provides insights into the evolutionary origin of waterlogging-tolerantHorticulture research · 2026Article
- Deciphering the ceRNA Network in Alfalfa: Insights into Cold Stress Tolerance Mechanisms.Biomolecules · 2026Article
- Plant responses to cold stress: molecular and physiological adaptive mechanisms with breeding advances.Frontiers in plant science · 2026Review
- The MsNAC73-MsMPK3 Complex Modulates Salt Tolerance and Shoot Branching of Alfalfa via Activating MsPG2 and MsPAE12 Expressions.Plant biotechnology journal · 2025Article
- TrWRKY41: A WRKY Transcription Factor from White Clover Improves Cold Tolerance in Transgenic Arabidopsis.Plants (Basel, Switzerland) · 2025Article
- Integrative Physiological, Metabolomic and Transcriptomic Analyses Uncover the Mechanisms Underlying Differential Responses of TwoBiomolecules · 2025Article
- A chaperonin BnaC01.CCT8 contributes to silique length and seed weight by affecting auxin and jasmonic acid signalling in Brassica napus.Plant biotechnology journal · 2025Article
- Ancient allopolyploidy and specific subgenomic evolution drove the radiation of poplars and willows.Nature communications · 2025Article
- Molecular Networks Governing Plant Responses to Heat and Cold Stress.Plants (Basel, Switzerland) · 2025Review
- Plant Coping with Cold Stress: Molecular and Physiological Adaptive Mechanisms with Future Perspectives.Cells · 2025Review
- Unraveling the signaling pathways of plant cold stress: current insights and future directions.Frontiers in plant science · 2025Review
- Phosphorylation of auxin signaling repressor IAA8 by heat-responsive MPKs causes defective flower development.Plant physiology · 2024Article
27 more citing papers are in PubMed but not listed here.
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7 authors at 2 institutions in 1 country.
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Abstract
The expression of CBF (C-repeat-binding factor) genes is required for freezing tolerance in Arabidopsis thaliana. CBFs are positively regulated by INDUCER OF CBF EXPRESSION1 (ICE1) and negatively regulated by MYB15. These transcription factors directly interact with specific elements in the CBF promoters. Mitogen-activated protein kinase (MAPK/MPK) cascades function upstream to regulate CBFs. However, the mechanism by which MPKs control CBF expression during cold stress signaling remains unknown. This study showed that the activity of MYB15, a transcriptional repressor of cold signaling, is regulated by MPK6-mediated phosphorylation. MYB15 specifically interacts with MPK6, and MPK6 phosphorylates MYB15 on Ser168. MPK6-induced phosphorylation reduced the affinity of MYB15 binding to the CBF3 promoter and mutation of its phosphorylation site (MYB15S168A) enhanced the transcriptional repression of CBF3 by MYB15. Furthermore, transgenic plants overexpressing MYB15S168A showed significantly reduced CBF transcript levels in response to cold stress, compared with plants overexpressing MYB15. The MYB15S168A-overexpressing plants were also more sensitive to freezing than MYB15-overexpressing plants. These results suggest that MPK6-mediated regulation of MYB15 plays an important role in cold stress signaling in Arabidopsis.
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