ArticleeLife2017
Identification of octopaminergic neurons that modulate sleep suppression by male sex drive.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 79 citations in OpenAlex.
- Mating imperatives drive plasticity of the daily temporal niche in fruit flies.Nature ecology & evolution · 2026Article
- A male-biased hypothalamic circuit modulates postmating sleep suppression in mice.Science advances · 2026Article
- Octopamine regulates neural circuits in the mushroom body and central complex, influencing sleep and arousal.iScience · 2026Article
- Sleep regulation inFrontiers in neuroscience · 2026Review
- Energy Deficit Is a Key Driver of Sleep Homeostasis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A switch in arousal circuit architecture shapes sleep across the lifespan.bioRxiv : the preprint server for biology · 2025Article
- Developmental sleep reallocation enables metabolic adaptation in desert flies.bioRxiv : the preprint server for biology · 2025Article
- Activity Monitoring for Analysis of Sleep inCold Spring Harbor protocols · 2024Article
- Socialization causes long-lasting behavioral changes.Scientific reports · 2024Article
- Divergent evolution of sleep in Drosophila species.Nature communications · 2024Article
- Sleep deprivation drives brain-wide changes in cholinergic presynapse abundance inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- The synaptic basis for sexual dimorphism in the invertebrate nervous system.Current opinion in neurobiology · 2023Review
- Modulation and neural correlates of postmating sleep plasticity in Drosophila females.Current biology : CB · 2023Article
- Regulation of sleep by cholinergic neurons located outside the central brain in Drosophila.PLoS biology · 2023Article
- Mechanisms of Sleep/Wake Regulation under Hypodopaminergic State: Insights from MitoPark Mouse Model of Parkinson's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Many faces of sleep regulation: beyond the time of day and prior wake time.The FEBS journal · 2023Review
- Polyphasic circadian neural circuits drive differential activities in multiple downstream rhythmic centers.Current biology : CB · 2023Article
- Sleep deprivation, sleep fragmentation, and social jet lag increase temperature preference inFrontiers in neuroscience · 2023Article
- Understanding the impact of sociosexual interactions on sleep usingFrontiers in physiology · 2023Article
- Neural Control of Action Selection Among Innate Behaviors.Neuroscience bulletin · 2022Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Molecular and circuit mechanisms for balancing competing drives are not well understood. While circadian and homeostatic mechanisms generally ensure sufficient sleep at night, other pressing needs can overcome sleep drive. Here, we demonstrate that the balance between sleep and sex drives determines whether male flies sleep or court, and identify a subset of octopaminergic neurons (MS1) that regulate sleep specifically in males. When MS1 neurons are activated, isolated males sleep less, and when MS1 neurons are silenced, the normal male sleep suppression in female presence is attenuated and mating behavior is impaired. MS1 neurons do not express the sexually dimorphic FRUITLESS (FRU) transcription factor, but form male-specific contacts with FRU-expressing neurons; calcium imaging experiments reveal bidirectional functional connectivity between MS1 and FRU neurons. We propose octopaminergic MS1 neurons interact with the FRU network to mediate sleep suppression by male sex drive.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.