ArticleChembiochem : a European journal of chemical biology2017
Efflux Pumps Might Not Be the Major Drivers of QAC Resistance in Methicillin-Resistant Staphylococcus aureus.
Article in Chembiochem : a European journal of chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 44 citations in OpenAlex.
- Water-Soluble Ammonium BODIPYs: Synthesis, Photophysics, Photogelation, and Antimicrobial Activity.Chemistry, an Asian journal · 2026Article
- Mechanism and Molecular Design Principles of Cationic Surfactants: From Charge-Driven Membrane Interactions to Next-Generation Quaternary Ammonium Compounds.ChemMedChem · 2026Review
- ADME/Tox study and the effect of β-Caryophyllene on the resistant strain ofToxicology reports · 2025Article
- Self-Assembly, Antimicrobial Properties and Biodegradability of Ester-Functionalized Choline-Based Surface-Active Ionic Liquids.Molecules (Basel, Switzerland) · 2025Article
- The mobilome landscape of biocide-resistance in Brazilian ESKAPE isolates.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Highly Effective Biocides againstACS infectious diseases · 2024Article
- Naturally derived 3-aminoquinuclidine salts as new promising therapeutic agents.Scientific reports · 2024Article
- Advancing Antimicrobial Textiles: A Comprehensive Study on Combating ESKAPE Pathogens and Ensuring User Safety.Materials (Basel, Switzerland) · 2024Article
- Deriving Novel Quaternary Ammonium Compound Disinfectant Scaffolds from a Natural Product: Mechanistic Insights of the Quaternization of Ianthelliformisamine C.ChemMedChem · 2023Article
- Further Study of the Polar Group's Influence on the Antibacterial Activity of the 3-Substituted Quinuclidine Salts with Long Alkyl Chains.Antibiotics (Basel, Switzerland) · 2023Article
- Synthesis and Biological Evaluation of 3-Amidoquinuclidine Quaternary Ammonium Compounds as New Soft Antibacterial Agents.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Impact of benzalkonium chloride, benzethonium chloride and chloroxylenol on bacterial antimicrobial resistance.Journal of applied microbiology · 2022Review
- New Membrane Active Antibacterial and Antiviral Amphiphiles Derived from Heterocyclic Backbone of Pyridinium-4-Aldoxime.Pharmaceuticals (Basel, Switzerland) · 2022Article
- In-Membrane Nanostructuring of Cationic Amphiphiles Affects Their Antimicrobial Efficacy and Cytotoxicity: A Comparison Study between a De Novo Antimicrobial Lipopeptide and Traditional Biocides.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Merging antimicrobial and visible emission properties within 1,3,4-trisubstituted-1,2,3-triazolium salts.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2022Article
- Assessing the risk of resistance to cationic biocides incorporating realism-based and biophysical approaches.Journal of industrial microbiology & biotechnology · 2022Review
- Chlorhexidine gluconate usage is associated with antiseptic tolerance in staphylococci from the neonatal intensive care unit.JAC-antimicrobial resistance · 2021Article
- An Efficient Synthesis of 3-Alkylpyridine Alkaloids Enables Their Biological Evaluation.ChemMedChem · 2021Article
- Back to Basics: Choosing the Appropriate Surface Disinfectant.Antibiotics (Basel, Switzerland) · 2021Review
- The silent pandemic: Emergent antibiotic resistances following the global response to SARS-CoV-2.iScience · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Quaternary ammonium compounds (QACs) are commonly used antiseptics that are now known to be subject to bacterial resistance. The prevalence and mechanisms of such resistance, however, remain underexplored. We investigated a variety of QACs, including those with multicationic structures (multiQACs), and the resistance displayed by a variety of Staphylococcus aureus strains with and without genes encoding efflux pumps, the purported main driver of bacterial resistance in MRSA. Through minimum inhibitory concentration (MIC)-, kinetic-, and efflux-based assays, we found that neither the qacR/qacA system present in S. aureus nor another efflux pump system is the main reason for bacterial resistance to QACs. Our findings suggest that membrane composition could be the predominant driver that allows CA-MRSA to withstand the assault of conventional QAC antiseptics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.