ArticleAngewandte Chemie (International ed. in English)2017
A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14-3-3.
Article in Angewandte Chemie (International ed. in English), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed.
- Modular protein frameworks via supramolecular synthons.Biophysical reviews · 2025Review
- Making and Breaking Supramolecular Synthons for Modular Protein Frameworks.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- How Do Molecular Tweezers Bind to Proteins? Lessons from X-ray Crystallography.Molecules (Basel, Switzerland) · 2024Review
- Cucurbit[8]uril Binds Nonterminal Dipeptide Sites with High Affinity and Induces a Type II β-Turn.Journal of the American Chemical Society · 2024Article
- Supramolecular Synthons in Protein-Ligand Frameworks.Crystal growth & design · 2024Article
- A supramolecular cucurbit[8]uril-based rotaxane chemosensor for the optical tryptophan detection in human serum and urine.Nature communications · 2023Article
- On-Resin Recognition of Aromatic Oligopeptides and Proteins through Host-Enhanced Heterodimerization.Journal of the American Chemical Society · 2022Article
- Molecular Approaches to Protein Dimerization: Opportunities for Supramolecular Chemistry.Frontiers in chemistry · 2022Review
- Segregated Protein-Cucurbit[7]uril Crystalline Architectures via Modulatory Peptide Tectons.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Design and recognition of cucurbituril-secured platinum-bound oligopeptides.Chemical science · 2021Article
- Toward Light-Controlled Supramolecular Peptide Dimerization.The Journal of organic chemistry · 2021Article
- Light-driven release of cucurbit[8]uril from a bivalent cage.Chemical science · 2021Article
- Specific inhibition of the Survivin-CRM1 interaction by peptide-modified molecular tweezers.Nature communications · 2021Article
- Noncovalent Protein-Pseudorotaxane Assembly Incorporating an Extended Arm Calix[8]arene with α-Helical Recognition Properties.Crystal growth & design · 2021Article
- Facile Fabrication of Protein-Macrocycle Frameworks.Journal of the American Chemical Society · 2021Article
- Similarity of the non-amyloid-β component and C-terminal tail of monomeric and tetrameric alpha-synuclein with 14-3-3 sigma.Computational and structural biotechnology journal · 2021Article
- Selective Recognition of Amino Acids and Peptides by Small Supramolecular Receptors.Molecules (Basel, Switzerland) · 2020Review
- A new soaking procedure for X-ray crystallographic structural determination of protein-peptide complexes.Acta crystallographica. Section F, Structural biology communications · 2020Article
- Atomic Details of Carbon-Based Nanomolecules Interacting with Proteins.Molecules (Basel, Switzerland) · 2020Review
- Ultra-large chemical libraries for the discovery of high-affinity peptide binders.Nature communications · 2020Article
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Authors and funding
6 authors.
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Abstract
Interactions between proteins frequently involve recognition sequences based on multivalent binding events. Dimeric 14-3-3 adapter proteins are a prominent example and typically bind partner proteins in a phosphorylation-dependent mono- or bivalent manner. Herein we describe the development of a cucurbit[8]uril (Q8)-based supramolecular system, which in conjunction with the 14-3-3 protein dimer acts as a binary and bivalent protein assembly platform. We fused the phenylalanine-glycine-glycine (FGG) tripeptide motif to the N-terminus of the 14-3-3-binding epitope of the estrogen receptor α (ERα) for selective binding to Q8. Q8-induced dimerization of the ERα epitope augmented its affinity towards 14-3-3 through a binary bivalent binding mode. The crystal structure of the Q8-induced ternary complex revealed molecular insight into the multiple supramolecular interactions between the protein, the peptide, and Q8.
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