ReviewBiophysical reviews2011
Filamin structure, function and mechanics: are altered filamin-mediated force responses associated with human disease?
Review in Biophysical reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Global transcriptional changes across multiple isogeniciScience · 2026Article
- Drak is a potential binding partner of Drosophila Filamin.Biology open · 2026Article
- Deciphering the impact of genetic variants on vulnerability to Opioid Use Disorder.Frontiers in cellular neuroscience · 2026Article
- Alpha-actinin-1, profilin-1, filamin-A, integrin alpha-M and glutathione synthase were identified to be associated with cognitive and social functions of schizophrenia.Scientific reports · 2025Article
- Filamin A in focus: unravelling the multifaceted roles of filamin A in neurodevelopment and neurological disorders.Brain : a journal of neurology · 2025Review
- Molecular flexibility of hyaluronic acid has a profound effect on invasion of cancer cells.Royal Society open science · 2025Article
- Article
- Humanising nanotoxicology: replacement of animal-derived products in the application of integrated approaches to testing and assessment of nanomaterial inhalation hazard.Frontiers in bioengineering and biotechnology · 2025Article
- Interaction of Filamin C With Actin Is Essential for Cardiac Development and Function.Circulation research · 2023Article
- A Further Case of Larsen's Syndrome: Clinical and Genotypic Challenges in Diagnosis.Journal of pediatric genetics · 2022Article
- A protective role for <i>Drosophila</i> Filamin in nephrocytes via Yorkie mediated hypertrophy.Life science alliance · 2022Article
- Drug affinity-responsive target stability unveils filamins as biological targets for artemetin, an anti-cancer flavonoid.Frontiers in molecular biosciences · 2022Article
- NudC L279P Mutation Destabilizes Filamin A by Inhibiting the Hsp90 Chaperoning Pathway and Suppresses Cell Migration.Frontiers in cell and developmental biology · 2021Article
- Small heat-shock proteins and their role in mechanical stress.Cell stress & chaperones · 2020Review
- Clues beyond the lung: an unusual diagnosis in an infant with chronic lung disease.Breathe (Sheffield, England) · 2020Article
- Postnatal Role of the Cytoskeleton in Adult Epileptogenesis.Cerebral cortex communications · 2020Article
- HspB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C.Science advances · 2019Article
- Skeletal Dysplasia Mutations Effect on Human Filamins' Structure and Mechanosensing.Scientific reports · 2017Article
- A proteomic approach to understanding the pathogenesis of idiopathic macular hole formation.Clinical proteomics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cytoskeleton framework is essential not only for cell structure and stability but also for dynamic processes such as cell migration, division and differentiation. The F-actin cytoskeleton is mechanically stabilised and regulated by various actin-binding proteins, one family of which are the filamins that cross-link F-actin into networks that greatly alter the elastic properties of the cytoskeleton. Filamins also interact with cell membrane-associated extracellular matrix receptors and intracellular signalling proteins providing a potential mechanism for cells to sense their external environment by linking these signalling systems. The stiffness of the external matrix to which cells are attached is an important environmental variable for cellular behaviour. In order for a cell to probe matrix stiffness, a mechanosensing mechanism functioning via alteration of protein structure and/or binding events in response to external tension is required. Current structural, mechanical, biochemical and human disease-associated evidence suggests filamins are good candidates for a role in mechanosensing.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.