Evidence map›Paper›PMID 28510209›Full record

ArticleBiophysical reviews2012

Nonlinear optical microscopy in decoding arterial diseases.

Alex C-T Ko, Andrew Ridsdale, Leila B Mostaço-Guidolin, Arkady Major, Albert Stolow, Michael G Sowa

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Scattering of Light from the Systemic Circulatory System.Diagnostics (Basel, Switzerland) · 2020
    Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Alex C-T KoNational Research Council Canada, Institute for Biodiagnostics, 435 Ellice Avenue, Winnipeg, Manitoba, Canada, R3B 1Y6. alex.ko@nrc-cnrc.gc.ca.
Andrew RidsdaleNational Research Council Canada, Steacie Institute for Molecular Sciences, 100 Sussex Drive, Ottawa, Ontario, Canada, K1A 0R6.
Leila B Mostaço-GuidolinDepartment of Electrical and Computer Engineering, University of Manitoba, 75A Chancellor's Circle, Winnipeg, Manitoba, Canada, R3T 5V6.
Arkady MajorDepartment of Electrical and Computer Engineering, University of Manitoba, 75A Chancellor's Circle, Winnipeg, Manitoba, Canada, R3T 5V6.
Albert StolowNational Research Council Canada, Steacie Institute for Molecular Sciences, 100 Sussex Drive, Ottawa, Ontario, Canada, K1A 0R6.
Michael G SowaNational Research Council Canada, Institute for Biodiagnostics, 435 Ellice Avenue, Winnipeg, Manitoba, Canada, R3B 1Y6.
National Academies of Sciences, Engineering, and Medicine · USUniversity of Manitoba · CANational Research Council Canada · CANational Research Council Institute for Biodiagnostics · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathological understanding of arterial diseases is mainly attributable to histological observations based on conventional tissue staining protocols. The emerging development of nonlinear optical microscopy (NLOM), particularly in second-harmonic generation, two-photon excited fluorescence and coherent Raman scattering, provides a new venue to visualize pathological changes in the extracellular matrix caused by atherosclerosis progression. These techniques in general require minimal tissue preparation and offer rapid three-dimensional imaging. The capability of label-free microscopic imaging enables disease impact to be studied directly on the bulk artery tissue, thus minimally perturbing the sample. In this review, we look at recent progress in applications related to arterial disease imaging using various forms of NLOM.

Indexed as

ArteryAtherosclerosisCoherent anti-Stokes RamanNonlinear optical microscopySecond-harmonic generationTwo-photon excited fluorescence

Identifiers

PMID28510209
PMCPMC5425695
OpenAlexW2050813276

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.