Evidence map›Paper›PMID 28510153›Full record

ReviewBiophysical reviews2009

Intercalated discs: multiple proteins perform multiple functions in non-failing and failing human hearts.

Colleen B Estigoy, Fredrik Pontén, Jacob Odeberg, Benjamin Herbert, Michael Guilhaus, Michael Charleston, Joshua W K Ho, Darryl Cameron, Cristobal G Dos Remedios

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biophysical reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Article
  6. Article
  7. Calpain Regulation and Dysregulation-Its Effects on the Intercalated Disk.International journal of molecular sciences · 2023
    Review
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  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Colleen B EstigoyBosch Institute, Department of Anatomy (F13), The University of Sydney, Sydney, 2006, Australia.
Fredrik PonténHuman Proteome Research Group, Uppsala University, Dag Hammaskjold 20, 751-85, Uppsala, Sweden.
Jacob OdebergDepartment of Biotechnology, Royal Institute of Technology, KTH AlbNov University Center, SE-10691, Stockholm, Sweden.
Benjamin HerbertProteomics Technology Centre of Expertise, University of Technology, Broadway, 2006, Australia.
Michael GuilhausBiomedical Mass Spectrometry Facility, University of New South Wales, Kensington, 2052, Australia.
Michael CharlestonSchool of Information Technology, The University of Sydney, Sydney, 2006, Australia.
Joshua W K HoBosch Institute, Department of Anatomy (F13), The University of Sydney, Sydney, 2006, Australia.
Darryl CameronBosch Institute, Department of Anatomy (F13), The University of Sydney, Sydney, 2006, Australia.
Cristobal G Dos RemediosBosch Institute, Department of Anatomy (F13), The University of Sydney, Sydney, 2006, Australia. crisdos@anatomy.usyd.edu.au.
University of Sydney · AURobert Bosch (Australia) · AUKTH Royal Institute of Technology · SEUniversity of Technology Sydney · AUUNSW Sydney · AUUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intercalated disc (ICD) occupies a central position in the transmission of force, electrical continuity and chemical communication between cardiomyocytes. Changes in its structure and composition are strongly implicated in heart failure. ICD functions include: maintenance of electrical continuity across the ICD; physical links between membranes and the cytoskeleton; intercellular adhesion; maintenance of ICD structure and function; and growth. About 200 known proteins are associated with ICDs, 40% of which change in disease. We systemically reviewed cardiac immunohistochemical data on the Human Protein Atlas (HPA) web site, ExPASy protein binding data and published papers on ICDs. We identified 43 proteins not previously reported, and confirmed 37 proteins that have previously been described. In addition, 102 proteins not present on the HPA web site but were described in ICDs in the literature. We group these into clusters that demonstrate functionally interactive groups of proteins demonstrating that ICDs play a key role in cardiomyocyte function.

Indexed as

Cardiac intercalated discChanges in diseaseFunctional protein groupsHuman heartImmunohistochemistry

Identifiers

PMID28510153
PMCPMC5418371
OpenAlexW2059499722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.