Evidence map›Paper›PMID 28510100›Full record

ReviewBiophysical reviews2015

Liposomal systems as carriers for bioactive compounds.

Ana Maria Sper Simão, Maytê Bolean, Thuanny Alexandra Campos Cury, Rodrigo Guerino Stabeli, Rosangela Itri, Pietro Ciancaglini

Open access · bronzeAbstract readReview
In one paragraph

Review in Biophysical reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 50 citations in OpenAlex.

  1. Trial
  2. Review
  3. Liposomal Formulation of Bioactive Substances fromInternational journal of molecular sciences · 2026
    Article
  4. Article
  5. Antitumor Effects of MicroencapsulatedMaterials (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Review
  8. Skin permeation and thermodynamic features of curcumin-loaded liposomes.Journal of materials science. Materials in medicine · 2020
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ana Maria Sper SimãoDepartmento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto (FFCLRP), Universidade de São Paulo (USP), Av. Bandeirantes, 3900, 14040-901, Ribeirão Preto, SP, Brazil.
Maytê BoleanDepartmento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto (FFCLRP), Universidade de São Paulo (USP), Av. Bandeirantes, 3900, 14040-901, Ribeirão Preto, SP, Brazil.
Thuanny Alexandra Campos CuryDepartmento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto (FFCLRP), Universidade de São Paulo (USP), Av. Bandeirantes, 3900, 14040-901, Ribeirão Preto, SP, Brazil.
Rodrigo Guerino StabeliCentro de Nanotecnologia Aplicada a Saúde-Nanosus, Presidência da Fiocruz, Rua Prof. Algacyr Munhoz Mader, 3775, 81350-010, Curitiba, PR, Brazil.
Rosangela ItriDepto. Física Aplicada, Instituto de Física, IF-USP, São Paulo, SP, Brazil.
Pietro CiancagliniDepartmento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto (FFCLRP), Universidade de São Paulo (USP), Av. Bandeirantes, 3900, 14040-901, Ribeirão Preto, SP, Brazil. pietro@ffclrp.usp.br.
Universidade de Ribeirão Preto · BRUniversidade de São Paulo · BRUniversidade Federal de Rondônia · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the revolutionary discovery that phospholipids can form closed bilayered structures in aqueous systems, the study of liposomes has become a very interesting area of research. The versatility and amazing biocompatibility of liposomes has resulted in their wide-spread use in many scientific fields, and many of their applications, especially in medicine, have yielded breakthroughs in recent decades. Specifically, their easy preparation and various structural aspects have given rise to broadly usable methodologies to internalize different compounds, with either lipophilic or hydrophilic properties. The study of compounds with potential biotechnological application(s) is generally related to evaluation and risk assessment of the possible cytotoxic or therapeutic effects of the compound under study. In most cases, undesirable side-effects are associated with an interaction of the liposome with the cell membrane and/or its absorption and subsequent interaction with a cellular biomolecule. Liposomal carrier systems have an unprecedented potential for delivering bioactive substances to specific molecular targets due to their biocompatibility, biodegradability and low toxicity. Liposomes are therefore considered to be an invaluable asset in applied biotechnology studies due to their potential for interaction with both hydrophilic and lipophilic compounds.

Indexed as

BiotechnologyCarrierDeliveryDrugsLiposome

Identifiers

PMID28510100
PMCPMC5418487
OpenAlexW1903500897

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.