ReviewBiophysical reviews2012
Toward a molecular understanding of nanoparticle-protein interactions.
Review in Biophysical reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed.
- Machine Learning Prediction of Protein Adsorption on Drug-delivering Nanoparticles: A Literature Survey and Need for Future Development.Pharmaceutical research · 2026Review
- Nanosystems Containing Proteins: From Fundamentals to Applications.Chemistry, an Asian journal · 2026Review
- Advancing glioblastoma therapy with surface-modified nanoparticles.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Machine Learning Enables Comprehensive Prediction of the Relative Protein Abundance of Multiple Proteins on the Protein Corona.Research (Washington, D.C.) · 2024Article
- Antimicrobial and Apoptotic Efficacy of Plant-Mediated Silver Nanoparticles.Molecules (Basel, Switzerland) · 2023Article
- Nanocarriers as a Delivery Platform for Anticancer Treatment: Biological Limits and Perspectives in B-Cell Malignancies.Pharmaceutics · 2022Review
- Sources of variability in nanoparticle uptake by cells.Nanoscale · 2021Article
- Biomolecular interactions with nanoparticles: applications for coronavirus disease 2019.Current opinion in colloid & interface science · 2021Review
- Environmental dimensions of the protein corona.Nature nanotechnology · 2021Review
- Kinetics of nanoparticle uptake into and distribution in human cells.Nanoscale advances · 2021Review
- Hard and Soft Protein Corona of Nanomaterials: Analysis and Relevance.Nanomaterials (Basel, Switzerland) · 2021Review
- Controlled Formation of a Protein Corona Composed of Denatured BSA on Upconversion Nanoparticles Improves Their Colloidal Stability.Materials (Basel, Switzerland) · 2021Article
- Using NMR Spectroscopy To Measure Protein Binding Capacity on Gold Nanoparticles.Journal of chemical education · 2020Article
- Physical Properties of Nanoparticles That Result in Improved Cancer Targeting.Journal of oncology · 2020Review
- Target Site Delivery and Residence of Nanomedicines: Application of Quantitative Systems Pharmacology.Pharmacological reviews · 2019Review
- Hybrid Nanogels: Stealth and Biocompatible Structures for Drug Delivery Applications.Pharmaceutics · 2019Review
- Systemic Bioequivalence Is Unlikely to Equal Target Site Bioequivalence for Nanotechnology Oncologic Products.The AAPS journal · 2019Review
- Effect on Platelet Function of Metal-Based Nanoparticles Developed for Medical Applications.Frontiers in cardiovascular medicine · 2019Review
- Protein Corona in Response to Flow: Effect on Protein Concentration and Structure.Biophysical journal · 2018Article
- Binding kinetics of ultrasmall gold nanoparticles with proteins.Nanoscale · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wherever nanoparticles (NPs) come in contact with a living organism, physical and chemical interactions take place between the surfaces of the NPs and biomatter, in particular proteins. When NP are exposed to biological fluids, an adsorption layer of proteins, a "protein corona" forms around the NPs. Consequently, living systems interact with the protein-coated NP rather than with a bare NP. To anticipate biological responses to NPs, we thus require comprehensive knowledge of the interactions at the bio-nano interface. In recent years, a wide variety of biophysical techniques have been employed to elucidate mechanistic aspects of NP-protein interactions. In this brief review, we present the latest findings regarding the composition of the protein corona as it forms on NPs in the blood stream. We also discuss molecular aspects of this adsorption layer and its time evolution. The current state of knowledge is summarized, and issues that still need to be addressed to further advance our understanding of NP-protein interactions are identified.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.