ReviewBiophysical reviews2011
Measuring the flow of molecules in cells.
Review in Biophysical reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Hippo signaling regulates the nuclear behavior and DNA binding times of YAP and TEAD to control transcription.Science advances · 2025Article
- Pair correlation microscopy of intracellular molecular transport.Nature protocols · 2025Review
- POPEYE intercellular localization mediates cell-specific iron deficiency responses.Plant physiology · 2022Article
- Back to the Future: Genetically Encoded Fluorescent Proteins as Inert Tracers of the Intracellular Environment.International journal of molecular sciences · 2020Review
- Stability of cytoplasmic nanoviscosity during cell cycle of HeLa cells synchronized with Aphidicolin.Scientific reports · 2019Article
- Comprehensive correlation analysis for super-resolution dynamic fingerprinting of cellular compartments using the Zeiss Airyscan detector.Nature communications · 2018Article
- Article
- Spatiotemporal regulation of Heterochromatin Protein 1-alpha oligomerization and dynamics in live cells.Scientific reports · 2015Article
- Article
- Morphogen transport.Development (Cambridge, England) · 2013Article
- Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset.Scientific reports · 2013Article
- Changes in chromatin compaction during the cell cycle revealed by micrometer-scale measurement of molecular flow in the nucleus.Biophysical journal · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
No methods proposed thus far have the capability to measure molecular flow in live cells at the single molecule level. Here, we review the potentiality of a newly established method based on the spatial correlation of fluorescence fluctuations at a pair of points in the sample (pair correlation method). The pair correlation function (pCF) offers a unique tool to probe the directionality of intracellular traffic, by measuring the accessibility of the cellular landscape and its role in determining the diffusive routes adopted by molecules. The sensitivity of the pCF method toward detection of barriers means that different structural elements of the cell can be tested in terms of penetrability and mechanisms of regulation imparted on molecular flow. This has been recently demonstrated in a series of studies looking at molecular transport inside live cells. Here, we will review the theory behind detection of barriers to molecular flow, the rules to interpret pCF data, and relevant applications to intracellular transport.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.