Evidence map›Paper›PMID 28510039›Full record

ReviewBiophysical reviews2010

Synaptopodin family of natively unfolded, actin binding proteins: physical properties and potential biological functions.

Joseph M Chalovich, Mechthild M Schroeter

Open access · bronzeAbstract readReview
In one paragraph

Review in Biophysical reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 33 citations in OpenAlex.

  1. Smooth muscle contractile cytoskeleton in health and disease.Journal of muscle research and cell motility · 2026
    Review
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  10. Review
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  13. Stabilization of Spine Synaptopodin by mGluR1 Is Required for mGluR-LTD.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  14. Nicotine, smoking, podocytes, and diabetic nephropathy.American journal of physiology. Renal physiology · 2021
    Article
  15. Recessive Mutations inKidney international reports · 2021
    Article
  16. Article
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joseph M ChalovichDepartment of Biochemistry and Molecular Biology, Brody School of Medicine at East Carolina University, 5E-122 Brody Medical Sciences Building, 600 Moye Blvd, Greenville, NC, 27834, USA. chalovichj@ecu.edu.
Mechthild M SchroeterDepartment of Physiology, University of Cologne, Robert-Koch-Str. 39, 50931, Cologne, Germany.
University of Cologne · DE

Funding

Acting Based Regulation of Smooth Muscle ContractionR01AR035216 · NIAMS · EAST CAROLINA UNIVERSITY · PI CHALOVICH, JOSEPH M · 1986 to 2007
$1.5M
NIAMS NIH HHS R01 AR035216
6 · The paper itself

Abstract

The synaptopodin family of proteins consists of at least 3 members: synaptopodin, the synaptopodin 2 proteins, and the synaptopodin 2-like proteins. Each family member has at least 3 isoforms that are produced by alternative splicing. Synaptopodin family members are basic proteins that are rich in proline and have little regular 2° or 3° structure at physiological temperature, pH and ionic strength. Like other natively unfolded proteins, synaptopodin family members have multiple binding partners including actin and other actin-binding proteins. Several members of the synaptopodin family have been shown to stimulate actin polymerization and to bundle actin filaments either on their own or in collaboration with other proteins. Synaptopodin 2 has been shown to accelerate nucleation of actin filament formation and to induce actin bundling. The actin polymerization activity is inhibited by Ca

Indexed as

Actin bundlingActin polymerizationCancerNatively unfoldedNuclear transportSynaptopodin

Identifiers

PMID28510039
PMCPMC5418383
OpenAlexW2059991608

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.