ArticleBiophysical reviews2015
Adaptations of cytoarchitecture in human dilated cardiomyopathy.
Article in Biophysical reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Lamin B1 loss in human cardiomyocytes is associated with nuclear shape deformation in dilated cardiomyopathy.Journal of molecular and cellular cardiology plus · 2026Article
- Critical contribution of mitochondria in the development of cardiomyopathy linked to desmin mutation.Stem cell research & therapy · 2024Article
- Affimers targeting proteins in the cardiomyocyte Z-disc: Novel tools that improve imaging of heart tissue.Frontiers in cardiovascular medicine · 2023Article
- Article
- Nanoscale regulation of L-type calcium channels differentiates between ischemic and dilated cardiomyopathies.EBioMedicine · 2020Article
- A note of appreciation for Prof. Cristobal dos Remedios on behalf of Biophysical Reviews.Biophysical reviews · 2019Article
- Non-sarcomeric causes of heart failure.Biophysical reviews · 2018Article
- Actin-associated proteins and cardiomyopathy-the 'unknown' beyond troponin and tropomyosin.Biophysical reviews · 2018Review
- Non-sarcomeric causes of heart failure: a Sydney Heart Bank perspective.Biophysical reviews · 2018Review
- Increased Cardiac Arrhythmogenesis Associated With Gap Junction Remodeling With Upregulation of RNA-Binding Protein FXR1.Circulation · 2018Article
- Label-free Imaging of Myocardial Remodeling in Atrial Fibrillation Using Nonlinear Optical Microscopy: A Feasibility Study.Journal of atrial fibrillation · 2018Article
- Insights from Second-Line Treatments for Idiopathic Dilated Cardiomyopathy.Journal of cardiovascular development and disease · 2017Article
- The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease.Biophysical reviews · 2017Review
- Cardiac cytoarchitecture - why the "hardware" is important for heart function!Biochimica et biophysica acta · 2016Review
- MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy.Nature communications · 2016Article
- Sarcoplasmic reticulum is an intermediary of mitochondrial and myofibrillar growth at the intercalated disc.Journal of muscle research and cell motility · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Hypertrophic cardiomyopathy is characterised by a histological phenotype of myocyte disarray, but heart tissue samples from patients with dilated cardiomyopathy (DCM) often look comparatively similar to those from healthy individuals apart from conspicuous regions of fibrosis and necrosis. We have previously investigated subcellular alterations in the cytoarchitecture of mouse models of dilated cardiomyopathy and found that both the organisation and composition of the intercalated disc, i.e. the specialised type of cell-cell contact in the heart, is altered. There is also is a change in the composition of the M-band of the sarcomere due to an expression shift towards the more extensible embryonic heart (EH)-myomesin isoform. Analysis of human samples from the Sydney Human Heart Tissue Bank have revealed similar structural findings and also provided evidence for a dramatic change in overall cardiomyocyte size control, which has also been seen in the mouse. Together these changes in cytoarchitecture probably contribute to the decreased functional output that is seen in DCM.
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Registered trials
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