Evidence map›Paper›PMID 28509904›Full record

Trial reportTranslational psychiatry2017

Immunological effects of behavioral activation with exercise in major depression: an exploratory randomized controlled trial.

F Euteneuer, K Dannehl, A Del Rey, H Engler, M Schedlowski, W Rief

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03731728 (The Effectiveness of Group CBT and Exercise in Management of Depression), which is not on this map. Cited by 52 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 9 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03731728 naterminatednot on this mapstarted 2019, after this paper: background citation

The Effectiveness of Group CBT and Exercise in Management of Depression: A Three Arm Randomized Controlled Pilot Trial

TypeinterventionalSponsorUniversity of AlbertaRan2019 to 2020Enrolled70ConditionsMajor Depressive DisorderArmsGroup CBT, Group exercise
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 9 syntheses or guidelines pooled it, 96 citations in OpenAlex.

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  17. Plants (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

F EuteneuerDivision of Clinical Psychology and Psychotherapy, Department of Psychology, Philipps University of Marburg, Marburg, Germany.
K DannehlDivision of Clinical Psychology and Psychotherapy, Department of Psychology, Philipps University of Marburg, Marburg, Germany.
A Del ReyResearch Group Immunophysiology, Institute of Physiology and Pathophysiology, Philipps University of Marburg, Marburg, Germany.
H EnglerInstitute of Medical Psychology and Behavioral Immunobiology, University Clinic Hospital Essen, University of Duisburg-Essen, Essen, Germany.
M SchedlowskiInstitute of Medical Psychology and Behavioral Immunobiology, University Clinic Hospital Essen, University of Duisburg-Essen, Essen, Germany.
W RiefDivision of Clinical Psychology and Psychotherapy, Department of Psychology, Philipps University of Marburg, Marburg, Germany.
Philipps University of Marburg · DEUniversity of Duisburg-Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Major depression (MD) is associated with peripheral inflammation and increased cardiovascular risk. Regular physical exercise can have anti-inflammatory effects. The present study examined whether behavioral activation with exercise affects inflammatory processes in MD. Ninety-eight patients with MD were randomly assigned to cognitive-behavioral therapy (CBT) emphasizing exercise during behavioral activation (CBT-E), CBT with pleasurable low-energy activities as an active control condition (CBT-C) or a passive waiting list control group (WL). Plasma levels of C-reactive protein (CRP), interleukin (IL)-6, IL-10, lipopolysaccharide (LPS)-stimulated IL-6 production, and blood immune cell counts were analyzed at baseline and weeks 8 (post-behavioral activation) and 16 (post-treatment). Thirty non-depressed age- and sex-matched controls were included to examine potential immunological alterations in MD at baseline. Patients with MD exhibited higher levels of CRP, higher neutrophil and monocyte counts, lower IL-10 levels and reduced LPS-stimulated IL-6 production compared to controls (P<0.001-0.045). Multilevel modeling indicated that CBT-E was associated with increased anti-inflammatory IL-10 at weeks 8 and 16 compared to CBT-C and WL (P=0.004-0.018). CBT-E did not significantly affect other immunological makers in the total sample. A subgroup analysis including patients with potentially higher cardiovascular risk (CRP ⩾1 μg ml

Indexed as

AdultCardiovascular DiseasesCell CountCognitive Behavioral TherapyC-Reactive ProteinExerciseExercise TherapyFemaleGermanyHumansInflammationInterleukin-10Interleukin-6LipopolysaccharidesMajor Depressive DisorderMaleC-Reactive ProteinIL10 protein, humanIL6 protein, humanInterleukin-10Interleukin-6Lipopolysaccharides

Identifiers

PMID28509904
PMCPMC5534946
OpenAlexW2616290066

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.