ArticleTranslational psychiatry2017
A continuum of genetic liability for minor and major depression.
Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04780152 (Assessment of Efficacy and Safety of Anodal Transcranial Direct Current Stimulation), which is not on this map. Cited by 30 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Efficacy and Safety of Anodal Transcranial Direct Current Stimulation (TDCS) in Pediatric and Teenage Patients With Major Depressive Disorder During COVID-19 Pandemics
Who cites it
30 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Sex-stratified genome-wide association meta-analysis of major depressive disorder.Nature communications · 2025Pooled it
- Structural connectivity associated with familial risk for mental illness: A meta-analysis of diffusion tensor imaging studies in relatives of patients with severe mental disorders.Human brain mapping · 2022Pooled it
- Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders.Translational psychiatry · 2021Pooled it
- Reward Processing in Depression: A Conceptual and Meta-Analytic Review Across fMRI and EEG Studies.The American journal of psychiatry · 2018Pooled it
- Common variants on 6q16.2, 12q24.31 and 16p13.3 are associated with major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Pooled it
- Molecular Basis Underlying Changes of Brain Entropy and Couplings in Late-life Depression.Current neuropharmacology · 2026Article
- Exploring the Mechanisms Linking Depression and Glaucoma: A Cohort Study of UK Biobank.Translational vision science & technology · 2025Article
- Dynamics of cerebral blood flow following sertraline treatment in adolescent depression.Frontiers in psychiatry · 2025Article
- Polysaccharides fromHeliyon · 2024Article
- Transcriptomic decoding of regional cortical vulnerability to major depressive disorder.Communications biology · 2024Article
- Altered intersubject functional variability of brain white-matter in major depressive disorder and its association with gene expression profiles.Human brain mapping · 2024Article
- Relative brain age is associated with socioeconomic status and anxiety/depression problems in youth.Developmental psychology · 2024Article
- Exploring the relationship between depression and delinquency: a sibling comparison design using the NLSY.Frontiers in psychology · 2024Article
- Association Between Single Nucleotide Polymorphisms Within lncRNA NONHSAT102891 and Depression Susceptibility in a Chinese Population.Neuropsychiatric disease and treatment · 2023Article
- Characterizing Heterogeneity in Neuroimaging, Cognition, Clinical Symptoms, and Genetics Among Patients With Late-Life Depression.JAMA psychiatry · 2022Article
- Familial risk for depressive and anxiety disorders: associations with genetic, clinical, and psychosocial vulnerabilities.Psychological medicine · 2022Article
- Exploring the genetic heterogeneity in major depression across diagnostic criteria.Molecular psychiatry · 2021Article
- Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents.BMC psychiatry · 2021Article
- Transcriptional-regulatory convergence across functional MDD risk variants identified by massively parallel reporter assays.Translational psychiatry · 2021Article
- Animal Models of Depression: What Can They Teach Us about the Human Disease?Diagnostics (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recent success of a large genome-wide association (GWA) study-analysing 130 620 major depression cases and 347 620 controls-in identifying the first single-nucleotide polymorphism (SNP) loci robustly associated with major depression in Europeans confirms that immense sample sizes are required to identify risk loci for depression. Given the phenotypic similarity between major depressive disorder (MDD) and the less severe minor depressive disorder (MiDD), we hypothesised that broadening the case definition to include MiDD may be an efficient approach to increase sample sizes in GWA studies of depression. By analysing two large twin pair cohorts, we show that minor depression and major depression lie on a single genetic continuum, with major depression being more severe but not aetiologically distinct from minor depression. Furthermore, we estimate heritabilities of 37% for minor depression, 46% for major depression and 48% for minor or major depression in a cohort of older adults (aged 50-92). However, the heritability of minor or major depression was estimated at 40% in a cohort of younger adults (aged 23-38). Moreover, two robust major depression-risk SNPs nominally associated with major depression in our Australian GWA data set produced more significant evidence for association with minor or major depression. Hence, broadening the case phenotype in GWA studies to include subthreshold definitions, such as MiDD, should facilitate the identification of additional genetic risk loci for depression.
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