Evidence map›Paper›PMID 28509707›Full record

ArticleCritical pathways in cardiology2017

Burden of Psychosocial and Cognitive Impairment in Patients With Atrial Fibrillation.

John A Bostrom, Jane S Saczynski, Alexandra Hajduk, Kevin Donahue, Lawrence S Rosenthal, Clifford Browning, Cynthia Ennis, Kevin C Floyd, Heather Richardson, Nada Esa and 2 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in Critical pathways in cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

John A BostromFrom the *Cardiology Division, Department of Medicine, University of Massachusetts Medical School, Worcester, MA; †Department of Pharmacy, Northeastern University, Boston, MA; ‡Epidemiology Division, Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA; §Section of Geriatrics, Department of Internal Medicine, Yale School of Medicine, New Haven, CT; ¶Center for Gerontology & Healthcare Research, Brown University School of Public Health, Providence, RI; and ‖National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA.
Jane S Saczynski
Alexandra Hajduk
Kevin Donahue
Lawrence S Rosenthal
Clifford Browning
Cynthia Ennis
Kevin C Floyd
Heather Richardson
Nada Esa
Jessica Ogarek
David D McManus
National Heart Lung and Blood Institute · USFramingham Heart Study · USYale University · US

Funding

University of Massachusetts Center for Clinical Science and Translational SupplementUL1TR001453 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LUZURIAGA, KATHERINE F · 2015 to 2024
$39.0M
TRACE-COREU01HL105268 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIEFE, CATARINA I. · 2010 to 2013
$5.8M
Systematic Assessment of Geriatric Elements in Atrial Fibrillation (SAGE-AF)R01HL126911 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MCMANUS, DAVID D., SACZYNSKI, JANE STEELE · 2016 to 2019
$3.2M
Final preclinical development of AAV gene therapy for atrial fibrillationR01HL130376 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DONAHUE, J KEVIN · 2016 to 2019
$2.9M
University of Massachusetts Center for Clinical and Translational ScienceKL2RR031981 · NCRR · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SULLIVAN, JOHN LEWIS · 2010 to 2011
$1.2M
Medical Illness & Cognitive Impairment in Older Adults: Heart Failure as a ModelK01AG033643 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SACZYNSKI, JANE STEELE · 2010 to 2014
$628k
NCATS NIH HHS UL1 TR001453NCRR NIH HHS KL2 RR031981NHLBI NIH HHS R01 HL126911NHLBI NIH HHS R01 HL130376NHLBI NIH HHS U01 HL105268NIA NIH HHS K01 AG033643
6 · The paper itself

Abstract

backgroundImpairments in psychosocial status and cognition relate to poor clinical outcomes in patients with atrial fibrillation (AF). However, how often these conditions co-occur and associations between burden of psychosocial and cognitive impairment and quality of life (QoL) have not been systematically examined in patients with AF.

methodsA total of 218 patients with symptomatic AF were enrolled in a prospective study of AF and psychosocial factors between May 2013 and October 2014 at the University of Massachusetts Medical Center. Cognitive function, depression, and anxiety were assessed at baseline and AF-specific QoL was assessed 6 months after enrollment using validated instruments. Demographic and clinical information were obtained from a structured interview and medical record review.

resultsThe mean age of the study participants was 63.5 ± 10.2 years, 35% were male, and 81% had paroxysmal AF. Prevalences of impairment in 1, 2, and 3 psychosocial/cognitive domains (eg, depression, anxiety, or cognition) were 75 (34.4%), 51 (23.4%), and 16 (7.3%), respectively. Patients with co-occurring psychosocial/cognitive impairments (eg, >1 domain) were older, more likely to smoke, had less education, and were more likely to have heart failure (all P < 0.05). Compared with participants with no psychosocial/cognitive impairments, AF-specific QoL at 6 months was significantly poorer among participants with baseline impairment in 2 (B = -13.6, 95% CI: -21.7 to -5.4) or 3 (B = -15.1, 95% CI: -28.0 to -2.2) psychosocial/cognitive domains.

conclusionDepression, anxiety, and impaired cognition were common in our cohort of patients with symptomatic AF and often co-occurred. Higher burden of psychosocial/cognitive impairment was associated with poorer AF-specific QoL.

Indexed as

Cost of IllnessQuality of LifeAgedAged, 80 and overAtrial FibrillationCognitive DysfunctionFemaleFollow-Up StudiesHumansMalePrevalenceProspective StudiesSeverity of Illness IndexSurveys and QuestionnairesUnited States

Identifiers

PMID28509707
PMCPMC5434700
OpenAlexW2614419891

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.