ArticleCEN case reports2012
Interaction of miconazole oral gel with warfarin and cyclosporine in a patient with nephrotic syndrome.
Article in CEN case reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
- Clinical analysis of the effects of azole antifungal agents on the anticoagulant activity of warfarin.Medicine · 2020Article
- Morbidity and mortality associated with the interaction of miconazole oral gel and warfarin.British dental journal · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well known that miconazole inhibits cytochrome P450 (CYP). However, this drug in oral gel form is believed not to absorb into systemic circulation, and therefore not to inhibit CYP. We experienced a case of increased oral bioavailability of warfarin and cyclosporine with this gel for treatment of oral candidiasis in a patient with nephrotic syndrome. Her prothrombin time-international normalized ratio (PT-INR) increased from 2 to 7.25, and the cyclosporine concentration at 2 h after final dosing (C2) increased from 633.8 to 1396.5 ng/ml 6 days after the coadministration. These problems were resolved by termination of the gel and switching to amphotericin B gargle. We further detected a significant amount of miconazole in her plasma, directly showing for the first time in a patient with this interaction that oral miconazole gel was actually absorbed into systemic circulation. Because warfarin and cyclosporine are often used simultaneously by nephrologists, caution should be applied with combined use of these drugs and oral miconazole gel to avoid adverse reaction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.