Evidence map›Paper›PMID 28508897›Full record

ArticleNature communications2017

Whole genome analysis of a schistosomiasis-transmitting freshwater snail.

Coen M Adema, LaDeana W Hillier, Catherine S Jones, Eric S Loker, Matty Knight, Patrick Minx, Guilherme Oliveira, Nithya Raghavan, Andrew Shedlock, Laurence Rodrigues do Amaral and 107 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 148 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed, 2 pooled it
26.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

148 citing papers in PubMed, 2 syntheses or guidelines pooled it, 311 citations in OpenAlex.

  1. Mapping molluscan endocrinology: a systematic and critical appraisal.Biological reviews of the Cambridge Philosophical Society · 2026
    Pooled it
  2. Pooled it
  3. Article
  4. Chromosome-Level Genome Assembly and Annotation of the Freshwater SnailAnimals : an open access journal from MDPI · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. FromFrontiers in immunology · 2025
    Review
  20. Article

88 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

117 authors at 20 institutions in 11 countries.

Coen M AdemaCenter for Theoretical and Evolutionary Immunology, Biology, University of New Mexico, Albuquerque New Mexico 87131 USA.
LaDeana W HillierThe McDonnell Genome Institute, Washington University, Saint Louis, Missouri 63108 USA.
Catherine S JonesInstitute of Biological and Environmental Sciences, School of Biological Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen AB24 2TZ, UK.
Eric S LokerCenter for Theoretical and Evolutionary Immunology, Biology, University of New Mexico, Albuquerque New Mexico 87131 USA.
Matty KnightDepartment of Microbiology, Immunology &Tropical Medicine and Research Center for Neglected Diseases of Poverty, School of Medicine &Health Sciences, The George Washington University, Washington, DC 20037, USA.
Patrick MinxThe McDonnell Genome Institute, Washington University, Saint Louis, Missouri 63108 USA.
Guilherme OliveiraRené Rachou Research Center, FIOCRUZ-Minas, Belo Horizonte, MG Brazil.ORCID 0000-0003-0054-3438
Nithya Raghavan
Andrew ShedlockCollege of Charleston, Biology Department, Medical University of South Carolina College of Graduate Studies Hollings Marine Laboratory Charleston, Charleston, South Carolina 29412 USA.
Laurence Rodrigues do AmaralLaboratory of Bioinformatics and Molecular Analysis, Institute of Genetics and Biochemistry Federal University of Uberlândia - Campus Patos de Minas (UFU), CEP 38700-128 Patos de Minas, Brasil.ORCID 0000-0003-4681-5451
Halime D Arican-GoktasDepartment of Life Sciences, College of Health and Life Sciences, Brunel University, London, Uxbridge UB8 3PH, UK.
Juliana G AssisRené Rachou Research Center, FIOCRUZ-Minas, Belo Horizonte, MG Brazil.
Elio Hideo BabaRené Rachou Research Center, FIOCRUZ-Minas, Belo Horizonte, MG Brazil.
Olga L BaronInstitut Sophia Agrobiotech, INRA/CNRS/UNS, Sophia Antipolis, France.
Christopher J BayneDepartment of Integrative Biology, Oregon State University, 3029 Cordley Hall, Corvallis, Oregon 97331 USA.
Utibe Bickham-WrightDepartment of Pathobiological Sciences, University of Wisconsin - School of Veterinary Medicine, 2015 Linden Dr Madison, Wisconsin 53706 USA.
Kyle K BiggarInstitute of Biochemisty and Department of Biology, Carleton University, Ottawa Ontario, Canada.
Michael BlouinDepartment of Integrative Biology, Oregon State University, 3029 Cordley Hall, Corvallis, Oregon 97331 USA.
Bryony C BonningIowa State University, Ames, Iowa 50011 USA.ORCID 0000-0002-9956-9613
Chris BotkaDepartment of Information Technology, Harvard Medical School, 107 Avenue Louis Pasteur, Boston, Massachusetts 02115 USA.
Joanna M BridgerDepartment of Life Sciences, College of Health and Life Sciences, Brunel University, London, Uxbridge UB8 3PH, UK.
Katherine M BuckleySunnybrook Health Sciences Centre, Department of Immunology, University of Toronto, 2075 Bayview Avenue, Rm. S126, Toronto, Ontario M4N 3M5, Canada.
Sarah K BuddenborgCenter for Theoretical and Evolutionary Immunology, Biology, University of New Mexico, Albuquerque New Mexico 87131 USA.
Roberta Lima CaldeiraLaboratorio de Helmintologia e Malacologia Médica, FIOCRUZ-Minas, René Rachou Research Center, Belo Horizonte, Brazil.
Julia CarletonDepartment of Human Genetics. University of Utah. 15 North 2030 East, Salt Lake City, Utah 84112, USA.
Omar S CarvalhoLaboratorio de Helmintologia e Malacologia Médica, FIOCRUZ-Minas, René Rachou Research Center, Belo Horizonte, Brazil.
Maria G CastilloBiology, New Mexico State University, Las Cruces, New Mexico 88003, USA.
Iain W ChalmersAnimal and Microbial Sciences Research Theme, IBERS, Aberystwyth University, Aberystwyth SY23 3FG, UK.
Mikkel ChristensensEMBL-EBI, Wellcome Genome Campus, CB10 1, UK.
Sandra CliftonThe McDonnell Genome Institute, Washington University, Saint Louis, Missouri 63108 USA.
Celine CosseauUniv. Perpignan Via Domitia, IHPE UMR 5244, CNRS, IFREMER, Univ. Montpellier, F-66860 Perpignan, France.
Christine CoustauInstitut Sophia Agrobiotech, INRA/CNRS/UNS, Sophia Antipolis, France.
Richard M CrippsDepartment of Biology, University of New Mexico, Albuquerque, New Mexico 87131, USA.
Yesid Cuesta-AstrozRené Rachou Research Center, FIOCRUZ-Minas, Belo Horizonte, MG Brazil.
Scott F CumminsFaculty of Science, Health and Education, University of the Sunshine Coast, Maroochydore, Queensland 4558, Australia.
Leon di StephanoThe Walter and Eliza Hall Institute for Medical Research 1G Royal Parade, Parkville, Victoria 3052 Australia.
Nathalie DinguirardDepartment of Pathobiological Sciences, University of Wisconsin - School of Veterinary Medicine, 2015 Linden Dr Madison, Wisconsin 53706 USA.
David DuvalUniv. Perpignan Via Domitia, IHPE UMR 5244, CNRS, IFREMER, Univ. Montpellier, F-66860 Perpignan, France.
Scott EmrichGenomics and Bioinformatics Core Facility, 19 Galvin Life Sciences, University of Notre Dame, Notre Dame, Indiana 46556 USA.
Cédric FeschotteDepartment of Human Genetics. University of Utah. 15 North 2030 East, Salt Lake City, Utah 84112, USA.
Rene FeyereisenUniversity of Copenhagen, Faculty of Science, Department of Plant and Environmental Sciences, Thorvaldsensvej 40, 1871 Frederiksberg C, Denmark.
Peter FitzGeraldGenome Analysis Unit, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Catrina FronickThe McDonnell Genome Institute, Washington University, Saint Louis, Missouri 63108 USA.
Lucinda FultonThe McDonnell Genome Institute, Washington University, Saint Louis, Missouri 63108 USA.
Richard GalinierUniv. Perpignan Via Domitia, IHPE UMR 5244, CNRS, IFREMER, Univ. Montpellier, F-66860 Perpignan, France.
Sandra G GavaRené Rachou Research Center, FIOCRUZ-Minas, Belo Horizonte, MG Brazil.ORCID 0000-0002-7464-7339
Michael GeuszBiological Sciences, Bowling Green State University, Bowling Green, Ohio 43403 USA.
Kathrin K GeyerAnimal and Microbial Sciences Research Theme, IBERS, Aberystwyth University, Aberystwyth SY23 3FG, UK.
Gloria I Giraldo-CalderónGenomics and Bioinformatics Core Facility, 19 Galvin Life Sciences, University of Notre Dame, Notre Dame, Indiana 46556 USA.
Matheus de Souza GomesLaboratory of Bioinformatics and Molecular Analysis, Institute of Genetics and Biochemistry Federal University of Uberlândia - Campus Patos de Minas (UFU), CEP 38700-128 Patos de Minas, Brasil.
Michelle A GordyBiological Sciences, Bowling Green State University, Bowling Green, Ohio 43403 USA.ORCID 0000-0002-5034-1765
Benjamin GourbalUniv. Perpignan Via Domitia, IHPE UMR 5244, CNRS, IFREMER, Univ. Montpellier, F-66860 Perpignan, France.
Christoph GrunauUniv. Perpignan Via Domitia, IHPE UMR 5244, CNRS, IFREMER, Univ. Montpellier, F-66860 Perpignan, France.
Patrick C HaningtonDepartment of Public Health Sciences, University of Alberta, 3-57F South Academic Building, Edmonton, Alberta T6G 1C9, Canada.
Karl F HoffmannAnimal and Microbial Sciences Research Theme, IBERS, Aberystwyth University, Aberystwyth SY23 3FG, UK.
Daniel HughesEMBL-EBI, Wellcome Genome Campus, CB10 1, UK.
Judith HumphriesDepartment of Biology, Lawrence University, Appleton Wisconsin 54911 USA.
Daniel J JacksonCourant Research Centre Geobiology, Georg-August University of Göttingen, Goldschmidtstraße 3, 37077 Göttingen, Germany.ORCID 0000-0001-9045-381X
Liana K Jannotti-PassosRené Rachou Research Center, FIOCRUZ-Minas, Belo Horizonte, MG Brazil.
Wander de Jesus JeremiasRené Rachou Research Center, FIOCRUZ-Minas, Belo Horizonte, MG Brazil.
Susan JoblingInstitute of Environment, Health &Societies, Environment and Health Theme, Brunel University London, Uxbridge UB8 3PH, UK.ORCID 0000-0002-9322-9597
Bishoy KamelDepartment of Biology, Pennsylvania State University, University Park, Pennsylvania 16802 USA.ORCID 0000-0003-2934-3827
Aurélie KapustaDepartment of Human Genetics. University of Utah. 15 North 2030 East, Salt Lake City, Utah 84112, USA.
Satwant KaurInstitute of Environment, Health &Societies, Environment and Health Theme, Brunel University London, Uxbridge UB8 3PH, UK.
Joris M KoeneFaculteit der Aard- en Levenswetenschappen, Vrije Universiteit, De Boelelaan 1085-1087 1081 HV Amsterdam, The Netherlands.
Andrea B KohnThe Whitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Blvd, St Augustine, Florida 32080, USA.
Dan LawsonEMBL-EBI, Wellcome Genome Campus, CB10 1, UK.
Scott P LawtonMolecular Parasitology Laboratory, School of Life Sciences Pharmacy and Chemistry, Kingston University, Kingston upon Thames, Surrey KT1 2EE. UK.
Di LiangFaculty of Science, Health and Education, University of the Sunshine Coast, Maroochydore, Queensland 4558, Australia.
Yanin LimpanontFaculty of Science, Health and Education, University of the Sunshine Coast, Maroochydore, Queensland 4558, Australia.
Sijun LiuIowa State University, Ames, Iowa 50011 USA.
Anne E LockyerInstitute of Environment, Health &Societies, Environment and Health Theme, Brunel University London, Uxbridge UB8 3PH, UK.
TyAnna L LovatoDepartment of Biology, University of New Mexico, Albuquerque, New Mexico 87131, USA.
Fernanda LudolfRené Rachou Research Center, FIOCRUZ-Minas, Belo Horizonte, MG Brazil.
Vince MagriniThe McDonnell Genome Institute, Washington University, Saint Louis, Missouri 63108 USA.
Donald P McManusMolecular Parasitology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Monica MedinaDepartment of Biology, Pennsylvania State University, University Park, Pennsylvania 16802 USA.
Milind MisraCenter for Theoretical and Evolutionary Immunology, Biology, University of New Mexico, Albuquerque New Mexico 87131 USA.
Guillaume MittaUniv. Perpignan Via Domitia, IHPE UMR 5244, CNRS, IFREMER, Univ. Montpellier, F-66860 Perpignan, France.
Gerald M MkojiKenya Medical Research Institute. P.O. Box 54840, 00200. Nairobi, Kenya.
Michael J MontagueDepartment of Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104 USA.ORCID 0000-0003-0253-4404
Cesar MontelongoBiology, New Mexico State University, Las Cruces, New Mexico 88003, USA.
Leonid L MorozThe Whitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Blvd, St Augustine, Florida 32080, USA.
Monica C Munoz-TorresBerkeley Bioinformatics Open-Source Projects, Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, One Cyclotron Road MS 977, Berkeley, California, 94720, USA.
Umar NiaziAnimal and Microbial Sciences Research Theme, IBERS, Aberystwyth University, Aberystwyth SY23 3FG, UK.
Leslie R NobleInstitute of Biological and Environmental Sciences, School of Biological Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen AB24 2TZ, UK.
Francislon S OliveiraRené Rachou Research Center, FIOCRUZ-Minas, Belo Horizonte, MG Brazil.
Fabiano S PaisRené Rachou Research Center, FIOCRUZ-Minas, Belo Horizonte, MG Brazil.
Anthony T PapenfussThe Walter and Eliza Hall Institute for Medical Research 1G Royal Parade, Parkville, Victoria 3052 Australia.ORCID 0000-0002-1102-8506
Rob PeaceDepartment of Systems and Computer Engineering, Carleton University, Ottawa Ontario, Canada.
Janeth J PenaCenter for Theoretical and Evolutionary Immunology, Biology, University of New Mexico, Albuquerque New Mexico 87131 USA.
Emmanuel A PilaDepartment of Public Health Sciences, University of Alberta, 3-57F South Academic Building, Edmonton, Alberta T6G 1C9, Canada.
Titouan QuelaisUniv. Perpignan Via Domitia, IHPE UMR 5244, CNRS, IFREMER, Univ. Montpellier, F-66860 Perpignan, France.
Brian J RaneyGenomics Institute, UC Santa Cruz, UC Santa Cruz, Santa Cruz, California 95064, USA.ORCID 0000-0002-9708-1390
Jonathan P RastSunnybrook Health Sciences Centre, Department of Immunology, University of Toronto, 2075 Bayview Avenue, Rm. S126, Toronto, Ontario M4N 3M5, Canada.
David RollinsonParasites and Vectors Division, London Centre for Neglected Tropical Disease Research, Wolfson Wellcome Biomedical Laboratories, Department of Life Sciences, Natural History Museum, Cromwell Road, London SW7 5BD, UK.ORCID 0000-0003-1999-1716
Izinara C RosseRené Rachou Research Center, FIOCRUZ-Minas, Belo Horizonte, MG Brazil.
Bronwyn RotgansFaculty of Science, Health and Education, University of the Sunshine Coast, Maroochydore, Queensland 4558, Australia.
Edwin J RoutledgeInstitute of Environment, Health &Societies, Environment and Health Theme, Brunel University London, Uxbridge UB8 3PH, UK.
Kathryn M RyanDepartment of Biology, University of New Mexico, Albuquerque, New Mexico 87131, USA.
Larissa L S ScholteRené Rachou Research Center, FIOCRUZ-Minas, Belo Horizonte, MG Brazil.
Kenneth B StoreyInstitute of Biochemisty and Department of Biology, Carleton University, Ottawa Ontario, Canada.
Martin SwainAnimal and Microbial Sciences Research Theme, IBERS, Aberystwyth University, Aberystwyth SY23 3FG, UK.
Jacob A TennessenDepartment of Integrative Biology, Oregon State University, 3029 Cordley Hall, Corvallis, Oregon 97331 USA.
Chad TomlinsonThe McDonnell Genome Institute, Washington University, Saint Louis, Missouri 63108 USA.
Damian L TrujilloDepartment of Biology, University of New Mexico, Albuquerque, New Mexico 87131, USA.
Emanuela V VolpiDepartment of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, 115 New Cavendish Street, London W1W 6UW, UK.
Anthony J WalkerMolecular Parasitology Laboratory, School of Life Sciences Pharmacy and Chemistry, Kingston University, Kingston upon Thames, Surrey KT1 2EE. UK.
Tianfang WangFaculty of Science, Health and Education, University of the Sunshine Coast, Maroochydore, Queensland 4558, Australia.
Ittiprasert WannapornDepartment of Microbiology, Immunology &Tropical Medicine and Research Center for Neglected Diseases of Poverty, School of Medicine &Health Sciences, The George Washington University, Washington, DC 20037, USA.
Wesley C WarrenThe McDonnell Genome Institute, Washington University, Saint Louis, Missouri 63108 USA.
Xiao-Jun WuDepartment of Pathobiological Sciences, University of Wisconsin - School of Veterinary Medicine, 2015 Linden Dr Madison, Wisconsin 53706 USA.
Timothy P YoshinoDepartment of Pathobiological Sciences, University of Wisconsin - School of Veterinary Medicine, 2015 Linden Dr Madison, Wisconsin 53706 USA.
Mohammed YusufLondon Centre for Nanotechnology,University College London, Gower Street, London WC1E 6BT, UK.
Si-Ming ZhangCenter for Theoretical and Evolutionary Immunology, Biology, University of New Mexico, Albuquerque New Mexico 87131 USA.
Min ZhaoFaculty of Science, Health and Education, University of the Sunshine Coast, Maroochydore, Queensland 4558, Australia.
Richard K WilsonThe McDonnell Genome Institute, Washington University, Saint Louis, Missouri 63108 USA.
Fundação Oswaldo Cruz · BRUniversity of New Mexico · USCentre National de la Recherche Scientifique · FRJames S. McDonnell Foundation · USBrunel University of London · GBUniversity of the Sunshine Coast · AUAberystwyth University · GBUniversity of Wisconsin System · USCarleton University · CAEuropean Bioinformatics Institute · GBOregon State University · USUniversity of Utah · USBowling Green State University · USCentro Universitário de Patos de Minas · BRIowa State University · USKingston University · GBNew Mexico State University · USPennsylvania State University · USSunnybrook Health Science Centre · CAUniversity of Aberdeen · GB

Funding

Large Scale Genome SequencingU54HG003079 · NHGRI · WASHINGTON UNIVERSITY · PI DUTCHER, SUSAN K · 2004 to 2016
$445.7M
The UCSC Genome BrowserU41HG002371 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI KENT, WILLIAM JAMES · 2012 to 2021
$36.6M
UNM Initiative to Maximize Student Diversity (IMSD)R25GM060201 · NIGMS · UNIVERSITY OF NEW MEXICO · PI WERNER-WASHBURNE, MARGRET C. · 2000 to 2017
$9.9M
UNM PREP (Post-baccalaureate Research Education ProgramR25GM075149 · NIGMS · UNIVERSITY OF NEW MEXICO · PI Kelly Miller · 2005 to 2026
$7.3M
GENETIC REGULATION OF MUSCLE FIBER DIVERSITYR01GM061738 · NIGMS · UNIVERSITY OF NEW MEXICO · PI CRIPPS, RICHARD MATTHEW · 2001 to 2022
$6.4M
Pilot Project ProgramP30GM110907 · NIGMS · UNIVERSITY OF NEW MEXICO · PI LOKER, ERIC SAMUEL · 2014 to 2018
$5.4M
Parasitology and Vector Biology Training ProgramT32AI007414 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI Lyric Colleen Bartholomay · 1992 to 2026
$4.5M
IMMUNOBIOLOGY OF SCHISTOSOME-MOLLUSK INTERACTIONSR01AI015503 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI YOSHINO, TIMOTHY P. · 1988 to 2014
$3.4M
UNDERLYING MECHANISMS OF SCHISTOSOME/SNAIL COMPATIBILITYR01AI016137 · NIAID · OREGON STATE UNIVERSITY · PI BAYNE, CHRISTOPHER JEFFREY · 1989 to 2012
$3.1M
Snail-Related Studies of Transmission and Control of Schistosomiasis in KenyaR01AI101438 · NIAID · UNIVERSITY OF NEW MEXICO · PI LOKER, ERIC SAMUEL · 2012 to 2016
$1.7M
Human DNA transposons: evolutionary history and genomic impactR01GM077582 · NIGMS · UNIVERSITY OF UTAH · PI FESCHOTTE, CEDRIC · 2007 to 2015
$1.4M
A new genetic mechanism in snails that controls transmission of schistosomesR01AI109134 · NIAID · OREGON STATE UNIVERSITY · PI BLOUIN, MICHAEL SCOTT · 2014 to 2016
$1.1M
National Centre for the Replacement, Refinement and Reduction of Animals in Research G0900802/1NHGRI NIH HHS U41 HG002371NHGRI NIH HHS U54 HG003079NIAID NIH HHS HHSN272201000005CNIAID NIH HHS HHSN272201000005INIAID NIH HHS HHSN272201400029CNIAID NIH HHS R01 AI015503NIAID NIH HHS R01 AI016137NIAID NIH HHS R01 AI101438NIAID NIH HHS R01 AI109134NIAID NIH HHS R21 AI016137NIAID NIH HHS R21 AI111201NIAID NIH HHS T32 AI007414NIGMS NIH HHS P30 GM110907NIGMS NIH HHS R01 GM061738NIGMS NIH HHS R01 GM077582NIGMS NIH HHS R25 GM060201NIGMS NIH HHS R25 GM075149
6 · The paper itself

Abstract

Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.

Indexed as

GenomeAnimal CommunicationAnimalsBiomphalariaDNA Transposable ElementsEvolution, MolecularFresh WaterGene Expression RegulationHost-Parasite InteractionsPheromonesProteomeSchistosoma mansoniSchistosomiasis mansoniSequence Analysis, DNAStress, PhysiologicalDNA Transposable ElementsPheromonesProteome

Identifiers

PMID28508897
PMCPMC5440852
OpenAlexW2616817562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.