ArticleObesity (Silver Spring, Md.)2017
Exome sequencing reveals novel genetic loci influencing obesity-related traits in Hispanic children.
Article in Obesity (Silver Spring, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Human genetic variation determines 24-hour rhythmic gene expression and disease risk.Nature communications · 2025Article
- Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children.The American journal of clinical nutrition · 2022Article
- Sequencing-based genome-wide association studies reporting standards.Cell genomics · 2021Article
- Exome variant discrepancies due to reference-genome differences.American journal of human genetics · 2021Article
- Unmapped exome reads implicate a role for Anelloviridae in childhood HIV-1 long-term non-progression.NPJ genomic medicine · 2021Article
- In Silico Structural and Biochemical Functional Analysis of a NovelInternational journal of molecular sciences · 2020Article
- Article
- Obesity genetics and cardiometabolic health: Potential for risk prediction.Diabetes, obesity & metabolism · 2019Review
- Relationship between Lipid Phenotypes, Overweight, Lipid Lowering Drug Response and KIF6 and HMG-CoA Genotypes in a Subset of the Brisighella Heart Study Population.International journal of molecular sciences · 2017Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveTo perform whole exome sequencing in 928 Hispanic children and identify variants and genes associated with childhood obesity.
methodsSingle-nucleotide variants (SNVs) were identified from Illumina whole exome sequencing data using integrated read mapping, variant calling, and an annotation pipeline (Mercury). Association analyses of 74 obesity-related traits and exonic variants were performed using SeqMeta software. Rare autosomal variants were analyzed using gene-based association analyses, and common autosomal variants were analyzed at the SNV level.
results(1) Rare exonic variants in 10 genes and 16 common SNVs in 11 genes that were associated with obesity traits in a cohort of Hispanic children were identified, (2) novel rare variants in peroxisome biogenesis factor 1 (PEX1) associated with several obesity traits (weight, weight z score, BMI, BMI z score, waist circumference, fat mass, trunk fat mass) were discovered, and (3) previously reported SNVs associated with childhood obesity were replicated.
conclusionsConvergence of whole exome sequencing, a family-based design, and extensive phenotyping discovered novel rare and common variants associated with childhood obesity. Linking PEX1 to obesity phenotypes poses a novel mechanism of peroxisomal biogenesis and metabolism underlying the development of childhood obesity.
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