ArticleEcoHealth2017
Estimating Loss of Brucella Abortus Antibodies from Age-Specific Serological Data In Elk.
Article in EcoHealth, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Seroprevalence of Brucellosis in Buffalo Worldwide and Associated Risk Factors: A Systematic Review and Meta-Analysis.Frontiers in veterinary science · 2021Pooled it
- Temporal dynamics of antibody level against Lyme disease bacteria in roe deer: Tale of a sentinel?Ecology and evolution · 2023Article
- Abortive vampire bat rabies infections in Peruvian peridomestic livestock.PLoS neglected tropical diseases · 2020Article
- Hidden cost of disease in a free-ranging ungulate: brucellosis reduces mid-winter pregnancy in elk.Ecology and evolution · 2018Article
- Winter feeding of elk in the Greater Yellowstone Ecosystem and its effects on disease dynamics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- The Certainty of Uncertainty: Potential Sources of Bias and Imprecision in Disease Ecology Studies.Frontiers in veterinary science · 2018Article
- Sociospatial structure explains marked variation in brucellosis seroprevalence in an Alpine ibex population.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serological data are one of the primary sources of information for disease monitoring in wildlife. However, the duration of the seropositive status of exposed individuals is almost always unknown for many free-ranging host species. Directly estimating rates of antibody loss typically requires difficult longitudinal sampling of individuals following seroconversion. Instead, we propose a Bayesian statistical approach linking age and serological data to a mechanistic epidemiological model to infer brucellosis infection, the probability of antibody loss, and recovery rates of elk (Cervus canadensis) in the Greater Yellowstone Ecosystem. We found that seroprevalence declined above the age of ten, with no evidence of disease-induced mortality. The probability of antibody loss was estimated to be 0.70 per year after a five-year period of seropositivity and the basic reproduction number for brucellosis to 2.13. Our results suggest that individuals are unlikely to become re-infected because models with this mechanism were unable to reproduce a significant decline in seroprevalence in older individuals. This study highlights the possible implications of antibody loss, which could bias our estimation of critical epidemiological parameters for wildlife disease management based on serological data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.