Trial reportEuropean journal of applied physiology2017
Oral L-menthol reduces thermal sensation, increases work-rate and extends time to exhaustion, in the heat at a fixed rating of perceived exertion.
Trial report in European journal of applied physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 8 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Effects of different menthol administration routes on endurance performance and physiological responses in the heat: a network meta-analysis.Frontiers in nutrition · 2026Pooled it
- Effects of carbohydrate, caffeine and menthol mouth rinses on exercise performance and ratings of perceived exertion: a systematic review and network meta-analysis.Frontiers in nutrition · 2026Pooled it
- Pooled it
- How Cool is That? The Effects of Menthol Mouth Rinsing on Exercise Capacity and Performance: A Systematic Review and Meta-analysis.Sports medicine - open · 2024Pooled it
- Performance Benefits of Pre- and Per-cooling on Self-paced Versus Constant Workload Exercise: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- Effects of internal cooling on physical performance, physiological and perceptional parameters when exercising in the heat: A systematic review with meta-analyses.Frontiers in physiology · 2023Pooled it
- Performance effects of internal pre- and per-cooling across different exercise and environmental conditions: A systematic review.Frontiers in nutrition · 2022Pooled it
- Menthol can be safely applied to improve thermal perception during physical exercise: a meta-analysis of randomized controlled trials.Scientific reports · 2020Pooled it
- Effects of carbohydrate-electrolyte solutions with and without L-menthol on hydration and performance recovery following simulated firefighting exercise.Journal of the International Society of Sports Nutrition · 2026Trial
- Peppermint essential oil (Mentha piperita L.) increases time to exhaustion in runners.European journal of nutrition · 2023Trial
- A Menthol-Enhanced "Cooling" Energy Gel Does Not Influence Laboratory Time Trial Performance in Trained Runners.Nutrients · 2023Trial
- Menthol Mouth Rinsing Maintains Relative Power Production during Three-Minute Maximal Cycling Performance in the Heat Compared to Cold Water and Placebo Rinsing.International journal of environmental research and public health · 2022Trial
- Trial
- Impact of elevated core temperature on cognition in hot environments within a military context.European journal of applied physiology · 2021Trial
- L-Menthol mouth rinse or ice slurry ingestion during the latter stages of exercise in the heat provide a novel stimulus to enhance performance despite elevation in mean body temperature.European journal of applied physiology · 2018Trial
- Nutritional Strategies to Support Performance Maintenance and Recovery in Football Under Hot Environmental Conditions: A Narrative Review.Nutrients · 2026Review
- Perspective: thermo-sensation to thermoregulation: advancing the anticipation debate via transient receptor potential (TRP) channels.European journal of applied physiology · 2026Review
- Nutrition for Tactical Athletes: Insights, Applications and Research Gaps.Sports medicine (Auckland, N.Z.) · 2026Review
- Topical application of the cold-mimetic l-menthol decreases wheel running without affecting the beneficial effects of voluntary exercise in mice.Experimental physiology · 2026Article
- Having the Heart to Exercise Control: Cardiac Interoception Influences Self-Paced Exercise Regulation.European journal of sport science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe study investigated the effect of a non-thermal cooling agent, L-menthol, on exercise at a fixed subjective rating of perceived exertion (RPE) in a hot environment.
methodEight male participants completed two trials at an exercise intensity between 'hard' and 'very hard', equating to 16 on the RPE scale at ~35 °C. Participants were instructed to continually adjust their power output to maintain an RPE of 16 throughout the exercise trial, stopping once power output had fallen by 30%. In a randomized crossover design, either L-menthol or placebo mouthwash was administered prior to exercise and at 10 min intervals. Power output, [Formula: see text]O
resultsExercise time was greater (23:23 ± 3:36 vs. 21:44 ± 2:32 min; P = 0.049) and average power output increased (173 ± 24 vs. 167 ± 24 W; P = 0.044) in the L-menthol condition. Peak isokinetic sprint power declined from pre-post trial in the L-menthol l (9.0%; P = 0.015) but not in the placebo condition (3.4%; P = 0.275). Thermal sensation was lower in the L-menthol condition (P = 0.036), despite no changes in skin or core temperature (P > 0.05).
conclusionThese results indicate that a non-thermal cooling mouth rinse lowered thermal sensation, resulting in an elevated work rate, which extended exercise time in the heat at a fixed RPE.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.