ArticleScience advances2017
Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries.
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Article in Science advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
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Who cites it
30 citing papers in PubMed.
- Endothelial Cell-Pericyte Crosstalk in the Brain Balances Microvascular Stability and Plasticity.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Beyond the genome: a rare case report of cutis laxa.AME case reports · 2026Article
- Lithium-induced neuroprotection in bipolar disorder: Translational insights into cytoskeletal and proteomic mechanisms.IBRO neuroscience reports · 2025Review
- Exploring skeletal disorders in cattle and sheep: a WGS-based framework for diagnosis and classification.Genetics, selection, evolution : GSE · 2025Article
- Induction of cardiac fibulin-4 protects against pressure overload-induced cardiac hypertrophy and heart failure.Communications biology · 2025Article
- A multiphasic model for determination of mouse ascending thoracic aorta mass transport properties with and without aneurysm.Biomechanics and modeling in mechanobiology · 2025Article
- Novel Insights into the Aortic Mechanical Properties of Mice Modeling Hereditary Aortic Diseases.Thrombosis and haemostasis · 2025Article
- Matrisome remodeling in the myocardium of hypertrophic cardiomyopathy; novel targets for molecular diagnostics.Frontiers in cell and developmental biology · 2025Review
- ZBTB46 coordinates angiogenesis and immunity to control tumor outcome.Nature immunology · 2024Article
- FBLN7 mediates vascular smooth muscle cell phenotype switching and vascular remodeling in hypertension.Theranostics · 2024Article
- Giant ascending aortic aneurysm with impending rupture as presentation of cutis laxa 1B: a case report.European heart journal. Case reports · 2023Article
- Characterization of a spontaneous mouse model of mild, accelerated aging via ECM degradation in emphysematous lungs.Scientific reports · 2023Article
- Changes in transmural mass transport correlate with ascending thoracic aortic aneurysm diameter in a fibulin-4 E57K knockin mouse model.American journal of physiology. Heart and circulatory physiology · 2023Article
- A new mouse model of elastin haploinsufficiency highlights the importance of elastin to vascular development and blood pressure regulation.Matrix biology : journal of the International Society for Matrix Biology · 2023Article
- Homeostatic, Non-Canonical Role of Macrophage Elastase in Vascular Integrity.Circulation research · 2023Article
- Protective Role of Endothelial Fibulin-4 in Valvulo-Arterial Integrity.Journal of the American Heart Association · 2023Article
- Soft-Tissue Material Properties and Mechanogenetics during Cardiovascular Development.Journal of cardiovascular development and disease · 2022Review
- Molecular Imaging of Aortic Aneurysm and Its Translational Power for Clinical Risk Assessment.Frontiers in medicine · 2022Review
- Role of Fibulins in Embryonic Stage Development and Their Involvement in Various Diseases.Biomolecules · 2021Review
- Dual role of endothelialScience translational medicine · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Carmen M HalabiDivision of Nephrology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Thomas J BroekelmannDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Michelle LinDivision of Nephrology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Vivian S LeeDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-0578-7781
Mon-Li ChuDepartment of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Robert P MechamDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Funding
Training of the Pediatric Physician-ScientistT32HD043010 · NICHD · WASHINGTON UNIVERSITY · PI MARK E. LOWE · 2002 to 2026
$6.4MChild Health Research CenterK12HD076224 · NICHD · WASHINGTON UNIVERSITY · PI MARK E. LOWE · 2013 to 2026
$6.2MPediatric Cardiovascular and Pulmonary Research Training Program.T32HL125241 · NHLBI · WASHINGTON UNIVERSITY · PI Juliane Bubeck Wardenburg, Kory J. Lavine · 2015 to 2026
$4.1MASSEMBLY OF LUNG ELASTINR01HL053325 · NHLBI · WASHINGTON UNIVERSITY · PI MECHAM, ROBERT P. · 1995 to 2019
$3.6MVESSEL STIFFENING, HYPERTENSION, AND VASCULAR EXTRACELLULAR MATRIXR01HL105314 · NHLBI · WASHINGTON UNIVERSITY · PI MECHAM, ROBERT P., WAGENSEIL, JESSICA · 2010 to 2018
$3.2MINTERDISCIPLINARY TRAINING IN MECHANOBIOLOGY FROM NM TO CMT32EB018266 · NIBIB · WASHINGTON UNIVERSITY · PI BAYLY, PHILIP V · 2014 to 2018
$987kLysyl Oxidase Mutations in Cardiovascular DiseaseF31HL136073 · NHLBI · WASHINGTON UNIVERSITY · PI LEE-KIM, VIVIAN · 2017 to 2018
$34kNHLBI NIH HHS F31 HL136073NHLBI NIH HHS R01 HL053325NHLBI NIH HHS R01 HL105314NHLBI NIH HHS T32 HL125241NIBIB NIH HHS T32 EB018266NICHD NIH HHS K12 HD076224NICHD NIH HHS T32 HD043010
Abstract
Homozygous or compound heterozygous mutations in fibulin-4 (
Indexed as
AnimalsAortaAortic AneurysmArteriesCardiovascular SystemCutis LaxaElastic TissueElastinExtracellular Matrix ProteinsFemaleHumansJoint InstabilityMaleMiceMice, Inbred C57BLMutationEFEMP2 protein, humanElastinExtracellular Matrix ProteinsProtein-Lysine 6-Oxidasearterial stiffnessascending aortic aneurysmcutis laxaelastic fiberextracellular matrixFibluin-4
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LicenceCC BY-NC
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.