Evidence map›Paper›PMID 28508060›Full record

ArticleScience advances2017

In vivo mapping of tissue- and subcellular-specific proteomes in

Aaron W Reinke, Raymond Mak, Emily R Troemel, Eric J Bennett

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 74 citations in OpenAlex.

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  15. Single-tissue proteomics inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. MACSPI enables tissue-selective proteomic and interactomic analyses in multicellular organisms.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Molecular Spatiomics by Proximity Labeling.Accounts of chemical research · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Aaron W ReinkeDivision of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.ORCID 0000-0001-7612-5342
Raymond MakDivision of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Emily R TroemelDivision of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.ORCID 0000-0003-2422-0473
Eric J BennettDivision of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
University of California San Diego · US

Funding

The Intracellular Pathogen Response Triggers Defense Against Co-evolved PathogensR01GM114139 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Emily R Troemel · 2015 to 2026
$3.1M
Probing organismal proteostasis through the response to intracellular infectionR01AG052622 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Emily R Troemel · 2017 to 2026
$2.7M
Manipulating Protein Homeostasis through Specialized Quality Control RibosomesDP2GM119132 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BENNETT, ERIC J · 2015 to 2015
$2.3M
Probing organismal proteostasis through the response to intracellular infectionR56AG052622 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TROEMEL, EMILY R · 2016 to 2016
$388k
NIA NIH HHS R01 AG052622NIA NIH HHS R56 AG052622NIGMS NIH HHS DP2 GM119132NIGMS NIH HHS R01 GM114139
6 · The paper itself

Abstract

Multicellular organisms are composed of tissues that have distinct functions requiring specialized proteomes. To define the proteome of a live animal with tissue and subcellular resolution, we adapted a localized proteomics technology for use in the multicellular model organism

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell NucleusCytoplasmGreen Fluorescent ProteinsProteomeProteomicsCaenorhabditis elegans ProteinsGreen Fluorescent ProteinsProteomeC. eleganschemical biologymass spectrometryprotein localizationspatially restricted enzymatic taggingtissue-specific expression

Identifiers

PMID28508060
PMCPMC5425238
OpenAlexW2949295459

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.