Evidence map›Paper›PMID 28507895›Full record

ArticleNeuroImage. Clinical2017

Diverging volumetric trajectories following pediatric traumatic brain injury.

Emily L Dennis, Joshua Faskowitz, Faisal Rashid, Talin Babikian, Richard Mink, Christopher Babbitt, Jeffrey Johnson, Christopher C Giza, Neda Jahanshad, Paul M Thompson and 1 more

Abstract read
In one paragraph

Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  20. Neuroimaging of the Injured Pediatric Brain: Methods and New Lessons.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Emily L DennisImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, CA 90292, USA. Electronic address: emily.dennis@ini.usc.edu.
Joshua FaskowitzImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, CA 90292, USA.
Faisal RashidImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, CA 90292, USA.
Talin BabikianDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA 90024, USA.
Richard MinkHarbor-UCLA Medical Center and Los Angeles BioMedical Research Institute, Department of Pediatrics, Torrance, CA 90509, USA.
Christopher BabbittMiller Children's Hospital, Long Beach, CA 90806, USA.
Jeffrey JohnsonLAC+USC Medical Center, Department of Pediatrics, Los Angeles, CA 90033, USA.
Christopher C GizaUCLA Brain Injury Research Center, UCLA Steve Tisch BrainSPORT Program, Dept of Neurosurgery and Division of Pediatric Neurology, Mattel Children's Hospital, Los Angeles, CA 90095, USA; Brain Research Institute, UCLA, Los Angeles, CA 90024, USA.
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, CA 90292, USA.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, CA 90292, USA; Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology, USC, Los Angeles, CA 90033, USA.
Robert F AsarnowDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA 90024, USA; Department of Psychology, UCLA, Los Angeles, CA 90024, USA; Brain Research Institute, UCLA, Los Angeles, CA 90024, USA.

Funding

TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2012 to 2022
$14.1M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Using glutamatergic pharmacotherapy to optimize TBI recoveryR01NS027544 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOVDA, DAVID A · 1990 to 2017
$3.8M
Reconnection of Neural Networks and Cognitive Recovery after Pediatric TBIR01HD061504 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ASARNOW, ROBERT F · 2010 to 2014
$2.9M
HARDI Mapping of Disease Effects on the BrainR01EB008432 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMPSON, PAUL M · 2009 to 2012
$2.6M
Alzheimer's disease risk analyzed using population imaging genomicsR01AG040060 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2011 to 2016
$2.5M
Predicting Brain Changes in HIV/AIDSR01NS080655 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NAVIA, BRADFORD, THOMPSON, PAUL M · 2012 to 2015
$2.3M
Longitudinal Tracking of Traumatic Brain Injury: Advanced ConnectomicsK99NS096116 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DENNIS, EMILY LARSEN · 2016 to 2017
$176k
NIA NIH HHS R01 AG040060NIBIB NIH HHS P41 EB015922NIBIB NIH HHS R01 EB008432NIBIB NIH HHS U54 EB020403NICHD NIH HHS R01 HD061504NINDS NIH HHS K99 NS096116NINDS NIH HHS R01 NS027544NINDS NIH HHS R01 NS080655
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is a significant public health concern, and can be especially disruptive in children, derailing on-going neuronal maturation in periods critical for cognitive development. There is considerable heterogeneity in post-injury outcomes, only partially explained by injury severity. Understanding the time course of recovery, and what factors may delay or promote recovery, will aid clinicians in decision-making and provide avenues for future mechanism-based therapeutics. We examined regional changes in brain volume in a pediatric/adolescent moderate-severe TBI (msTBI) cohort, assessed at two time points. Children were first assessed 2-5 months post-injury, and again 12 months later. We used tensor-based morphometry (TBM) to localize longitudinal volume expansion and reduction. We studied 21 msTBI patients (5 F, 8-18 years old) and 26 well-matched healthy control children, also assessed twice over the same interval. In a prior paper, we identified a subgroup of msTBI patients, based on interhemispheric transfer time (IHTT), with significant structural disruption of the white matter (WM) at 2-5 months post injury. We investigated how this subgroup (TBI-slow,

Indexed as

Disease ProgressionAdolescentAtrophyBrain Injuries, TraumaticChildCorpus CallosumFemaleFollow-Up StudiesHumansHypothalamusMagnetic Resonance ImagingMaleWhite MatterLongitudinalPediatricTensor-based morphometryTraumatic brain injury

Identifiers

PMID28507895
PMCPMC5423316

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.