Evidence map›Paper›PMID 28507882›Full record

ArticleGlobal spine journal2017

Aquaporin-1 Expression in Herniated Human Lumbar Intervertebral Discs.

Haydn Hoffman, Aaron W Choi, Victor Chang, Jon Kimball, Alan S Verkman, Rubeen Virani, Brian Kim, Tianyi Niu, Daniel C Lu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Global spine journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Current concepts for lumbar disc herniation.International orthopaedics · 2019
    Review
  3. Lumbar Disc Herniation.Current reviews in musculoskeletal medicine · 2017
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Haydn HoffmanUniversity of California, Los Angeles, CA, USA.
Aaron W ChoiUniversity of California, Los Angeles, CA, USA.
Victor ChangUniversity of California, Los Angeles, CA, USA.
Jon KimballUniversity of California, Los Angeles, CA, USA.
Alan S VerkmanUniversity of California, San Francisco, CA, USA.
Rubeen ViraniUniversity of California, Los Angeles, CA, USA.
Brian KimUniversity of California, Los Angeles, CA, USA.
Tianyi NiuUniversity of California, Los Angeles, CA, USA.
Daniel C LuUniversity of California, Los Angeles, CA, USA.
University of California, Los Angeles · USUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designCase series.

objectiveIntervertebral disc (IVD) degeneration is the cause of spondylosis. The pathogenesis is poorly understood, but disc dehydration often plays a role. In this study, we aim to identify and quantify aquaporin-1 (AQP1) in ex vivo human degenerated IVDs obtained intraoperatively and to investigate the relationship between AQP1 levels and magnetic resonance imaging (MRI) T2 intensity of the disc.

methodsEx vivo samples of nucleus pulposus (NP) tissue from lumbar IVDs were obtained from 18 consecutive patients who underwent surgery for disc herniation at L4/5 and L5/S1 level. Immunohistochemistry was performed to determine the presence of AQP1 expression, and this was quantified by Western blot analysis. AQP1 expression was compared to preoperative IVD signal intensity on T2-weighted MRI.

resultsNP tissue was obtained from 18 patients (9 for L4/5 level and 9 for L5/S1 level). AQP1 expression was detected in all samples by Western blot and immunohistochemistry. AQP1 expression had a linear correlation with the preoperative IVD signal intensity on T2-weighted MRI at L4/5 level (

conclusionsOur results show that AQP1 can be detected in IVD obtained from live human subjects. Increased AQP1 expression is associated with greater disc hydration as measured by signal intensity on T2-weighted MRI. AQP1 may have a role in the dehydration associated with disc degeneration.

Indexed as

aquaporin-1degenerative disc diseasedisc herniationMRIT2 intensity

Identifiers

PMID28507882
PMCPMC5415154
OpenAlexW2978696321

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.